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Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women.

Abstract

BACKGROUND

Acrylamide, a probable human carcinogen, can be formed in carbohydrate-rich foods cooked at high temperatures. Whether dietary acrylamide intake is associated with the risk of cancer in humans is uncertain. We aimed to assess the relation between dietary acrylamide intake and the incidence of epithelial ovarian cancer.

METHODS

The Swedish Mammography Cohort is a population-based prospective study of 61,057 Swedish women. Diet was assessed with a food-frequency questionnaire at baseline in 1987-1990 and again in 1997.

RESULTS

During a mean follow-up of 17.5 years, we ascertained 368 incident cases of ovarian cancer. We observed no association between acrylamide intake and the risk of ovarian cancer. Compared with the lowest quartile of acrylamide intake (mean intake, 16.9 microg/day), the multivariable rate ratios for the highest quartile (mean intake, 32.5 microg/day) were 0.86 (95% confidence interval, 0.63-1.16) for total ovarian cancer and 1.05 (95% confidence interval, 0.68-1.63) for serous ovarian cancer (n=182 cases).

CONCLUSIONS

The results from this prospective study provide no evidence that dietary acrylamide in amounts typically consumed by Swedish women is associated with the risk of ovarian cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19223560

Citation

Larsson, Susanna C., et al. "Long-term Dietary Acrylamide Intake and Risk of Epithelial Ovarian Cancer in a Prospective Cohort of Swedish Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 3, 2009, pp. 994-7.
Larsson SC, Akesson A, Wolk A. Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. Cancer Epidemiol Biomarkers Prev. 2009;18(3):994-7.
Larsson, S. C., Akesson, A., & Wolk, A. (2009). Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(3), pp. 994-7. doi:10.1158/1055-9965.EPI-08-0868.
Larsson SC, Akesson A, Wolk A. Long-term Dietary Acrylamide Intake and Risk of Epithelial Ovarian Cancer in a Prospective Cohort of Swedish Women. Cancer Epidemiol Biomarkers Prev. 2009;18(3):994-7. PubMed PMID: 19223560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. AU - Larsson,Susanna C, AU - Akesson,Agneta, AU - Wolk,Alicja, Y1 - 2009/02/17/ PY - 2009/2/19/entrez PY - 2009/2/19/pubmed PY - 2009/4/17/medline SP - 994 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 3 N2 - BACKGROUND: Acrylamide, a probable human carcinogen, can be formed in carbohydrate-rich foods cooked at high temperatures. Whether dietary acrylamide intake is associated with the risk of cancer in humans is uncertain. We aimed to assess the relation between dietary acrylamide intake and the incidence of epithelial ovarian cancer. METHODS: The Swedish Mammography Cohort is a population-based prospective study of 61,057 Swedish women. Diet was assessed with a food-frequency questionnaire at baseline in 1987-1990 and again in 1997. RESULTS: During a mean follow-up of 17.5 years, we ascertained 368 incident cases of ovarian cancer. We observed no association between acrylamide intake and the risk of ovarian cancer. Compared with the lowest quartile of acrylamide intake (mean intake, 16.9 microg/day), the multivariable rate ratios for the highest quartile (mean intake, 32.5 microg/day) were 0.86 (95% confidence interval, 0.63-1.16) for total ovarian cancer and 1.05 (95% confidence interval, 0.68-1.63) for serous ovarian cancer (n=182 cases). CONCLUSIONS: The results from this prospective study provide no evidence that dietary acrylamide in amounts typically consumed by Swedish women is associated with the risk of ovarian cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/19223560/Long_term_dietary_acrylamide_intake_and_risk_of_epithelial_ovarian_cancer_in_a_prospective_cohort_of_Swedish_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19223560 DB - PRIME DP - Unbound Medicine ER -