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Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study).

Abstract

BACKGROUND

It is still unclear whether weight gain from early to late adulthood affects longevity. Furthermore, no study has addressed its association with all-cause and cause-specific mortality in an Asian population.

METHODS

We prospectively assessed the association between an increase in body mass index (BMI) category since age 20 years and risk of all-cause, cardiovascular disease (CVD) and cancer mortality. Self-reported information pertaining to BMI was collected from 38 080 Japanese men and women aged 40-79 years at study entry in 1994 after exclusion of participants with a BMI of <18.5 kg/m(2) at age 20 years or at study entry. We defined six patterns of increase in BMI category at age 20 years and study entry: stable normal, overweight and obese, normal to overweight or obese, and overweight to obese.

RESULTS

During 7 years of follow-up, 2617 participants died. After adjustment for potential confounders, we observed a significantly increased risk of all-cause mortality for the pattern of normal weight at age 20 years and obese at study entry and of stable obese compared with stable normal in BMI category, the multivariate HRs (95% confidence interval (CI)) being 1.42 (1.08-1.88) and 2.26 (1.45-3.51), respectively. For the pattern of overweight at age 20 years and obese at study entry, the multivariate hazard ratio (95% CI) was 1.35 (0.92-1.98). In contrast, we did not observe an increased risk of all-cause mortality for normal weight at age 20 years and overweight at study entry, and stable overweight. For CVD and cancer mortality, these results were consistently observed.

CONCLUSION

We observed an increased risk of all-cause mortality both among participants who had been persistently obese since early adulthood and participants who showed an increase in BMI category from normal to obese, compared with participants with a stable normal BMI category.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. tshimazu@ncc.go.jp

    , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Aged
    Asian Continental Ancestry Group
    Body Mass Index
    Body Weight
    Cardiovascular Diseases
    Cause of Death
    Female
    Humans
    Longevity
    Male
    Middle Aged
    Neoplasms
    Obesity
    Risk Factors
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19223845

    Citation

    Shimazu, T, et al. "Increase in Body Mass Index Category Since Age 20 Years and All-cause Mortality: a Prospective Cohort Study (the Ohsaki Study)." International Journal of Obesity (2005), vol. 33, no. 4, 2009, pp. 490-6.
    Shimazu T, Kuriyama S, Ohmori-Matsuda K, et al. Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study). Int J Obes (Lond). 2009;33(4):490-6.
    Shimazu, T., Kuriyama, S., Ohmori-Matsuda, K., Kikuchi, N., Nakaya, N., & Tsuji, I. (2009). Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study). International Journal of Obesity (2005), 33(4), pp. 490-6. doi:10.1038/ijo.2009.29.
    Shimazu T, et al. Increase in Body Mass Index Category Since Age 20 Years and All-cause Mortality: a Prospective Cohort Study (the Ohsaki Study). Int J Obes (Lond). 2009;33(4):490-6. PubMed PMID: 19223845.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study). AU - Shimazu,T, AU - Kuriyama,S, AU - Ohmori-Matsuda,K, AU - Kikuchi,N, AU - Nakaya,N, AU - Tsuji,I, Y1 - 2009/02/17/ PY - 2009/2/19/entrez PY - 2009/2/19/pubmed PY - 2010/4/9/medline SP - 490 EP - 6 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 33 IS - 4 N2 - BACKGROUND: It is still unclear whether weight gain from early to late adulthood affects longevity. Furthermore, no study has addressed its association with all-cause and cause-specific mortality in an Asian population. METHODS: We prospectively assessed the association between an increase in body mass index (BMI) category since age 20 years and risk of all-cause, cardiovascular disease (CVD) and cancer mortality. Self-reported information pertaining to BMI was collected from 38 080 Japanese men and women aged 40-79 years at study entry in 1994 after exclusion of participants with a BMI of <18.5 kg/m(2) at age 20 years or at study entry. We defined six patterns of increase in BMI category at age 20 years and study entry: stable normal, overweight and obese, normal to overweight or obese, and overweight to obese. RESULTS: During 7 years of follow-up, 2617 participants died. After adjustment for potential confounders, we observed a significantly increased risk of all-cause mortality for the pattern of normal weight at age 20 years and obese at study entry and of stable obese compared with stable normal in BMI category, the multivariate HRs (95% confidence interval (CI)) being 1.42 (1.08-1.88) and 2.26 (1.45-3.51), respectively. For the pattern of overweight at age 20 years and obese at study entry, the multivariate hazard ratio (95% CI) was 1.35 (0.92-1.98). In contrast, we did not observe an increased risk of all-cause mortality for normal weight at age 20 years and overweight at study entry, and stable overweight. For CVD and cancer mortality, these results were consistently observed. CONCLUSION: We observed an increased risk of all-cause mortality both among participants who had been persistently obese since early adulthood and participants who showed an increase in BMI category from normal to obese, compared with participants with a stable normal BMI category. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/19223845/Increase_in_body_mass_index_category_since_age_20_years_and_all_cause_mortality:_a_prospective_cohort_study__the_Ohsaki_Study__ L2 - http://dx.doi.org/10.1038/ijo.2009.29 DB - PRIME DP - Unbound Medicine ER -