Tags

Type your tag names separated by a space and hit enter

Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT.
J Glaucoma. 2009 Feb; 18(2):165-71.JG

Abstract

PURPOSE

To compare the detectability between glaucomatous visual field changes using standard automated perimetry (SAP), frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), and flicker perimetry and structural changes using optical coherence tomography (OCT).

PARTICIPANTS

Fifty-nine eyes of fifty-nine patients with open-angle glaucoma, 24 eyes of 24 glaucoma suspects (GSs), and 40 eyes of 40 healthy age-matched subjects.

METHODS

All subjects underwent Humphrey visual field analyzer II 24-2 full threshold (SAP), Swedish interactive threshold algorithm-SWAP, FDT (30-1, 30-5, 24-2-1, 24-2-5), flicker perimetry on Octopus 311 (4-zone probability 38S), and Stratus OCT [fast retinal nerve fiber layer thickness (NFLT) and fast optic disc]. To evaluate the visual field, FDT and flicker used the number of abnormal points, whereas SAP used mean deviation (MD) and SWAP used both the number of abnormal points and MD. The areas under the receiver operating characteristic curves [area under the curve (AUCs)] and sensitivities at fixed specificities were used to assess the detectability of glaucoma.

RESULTS

The AUC for FDT 30-1, 30-5, 24-2-1, 24-2-5, flicker perimetry, SWAP (MD), and SWAP (number of abnormal points) were 0.95, 0.94, 0.88, 0.89, 0.99, 0.88, and 0.88 in the early glaucoma group and 0.67, 0.69, 0.65, 0.70, 0.80, 0.64, and 0.66 in the GS group, respectively. In the early glaucoma and GS groups, all OCT parameters had an AUC >0.81 except the disc area parameter. Especially, average NFLT had the highest AUC of 0.94 in the OCT parameters.

CONCLUSIONS

FDT, SWAP, flicker perimetry, and OCT are all useful methods for discriminating between healthy eyes and eyes with early glaucoma. Among all 10 OCT parameters, NFLT has the highest sensitivity for detecting early glaucomatous changes in GS patients.

Authors+Show Affiliations

Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan. nomoto@ganka.med.kindai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19225357

Citation

Nomoto, Hiroki, et al. "Detectability of Glaucomatous Changes Using SAP, FDT, Flicker Perimetry, and OCT." Journal of Glaucoma, vol. 18, no. 2, 2009, pp. 165-71.
Nomoto H, Matsumoto C, Takada S, et al. Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT. J Glaucoma. 2009;18(2):165-71.
Nomoto, H., Matsumoto, C., Takada, S., Hashimoto, S., Arimura, E., Okuyama, S., & Shimomura, Y. (2009). Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT. Journal of Glaucoma, 18(2), 165-71. https://doi.org/10.1097/IJG.0b013e318179f7ca
Nomoto H, et al. Detectability of Glaucomatous Changes Using SAP, FDT, Flicker Perimetry, and OCT. J Glaucoma. 2009;18(2):165-71. PubMed PMID: 19225357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detectability of glaucomatous changes using SAP, FDT, flicker perimetry, and OCT. AU - Nomoto,Hiroki, AU - Matsumoto,Chota, AU - Takada,Sonoko, AU - Hashimoto,Shigeki, AU - Arimura,Eiko, AU - Okuyama,Sachiko, AU - Shimomura,Yoshikazu, PY - 2009/2/20/entrez PY - 2009/2/20/pubmed PY - 2009/5/27/medline SP - 165 EP - 71 JF - Journal of glaucoma JO - J. Glaucoma VL - 18 IS - 2 N2 - PURPOSE: To compare the detectability between glaucomatous visual field changes using standard automated perimetry (SAP), frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), and flicker perimetry and structural changes using optical coherence tomography (OCT). PARTICIPANTS: Fifty-nine eyes of fifty-nine patients with open-angle glaucoma, 24 eyes of 24 glaucoma suspects (GSs), and 40 eyes of 40 healthy age-matched subjects. METHODS: All subjects underwent Humphrey visual field analyzer II 24-2 full threshold (SAP), Swedish interactive threshold algorithm-SWAP, FDT (30-1, 30-5, 24-2-1, 24-2-5), flicker perimetry on Octopus 311 (4-zone probability 38S), and Stratus OCT [fast retinal nerve fiber layer thickness (NFLT) and fast optic disc]. To evaluate the visual field, FDT and flicker used the number of abnormal points, whereas SAP used mean deviation (MD) and SWAP used both the number of abnormal points and MD. The areas under the receiver operating characteristic curves [area under the curve (AUCs)] and sensitivities at fixed specificities were used to assess the detectability of glaucoma. RESULTS: The AUC for FDT 30-1, 30-5, 24-2-1, 24-2-5, flicker perimetry, SWAP (MD), and SWAP (number of abnormal points) were 0.95, 0.94, 0.88, 0.89, 0.99, 0.88, and 0.88 in the early glaucoma group and 0.67, 0.69, 0.65, 0.70, 0.80, 0.64, and 0.66 in the GS group, respectively. In the early glaucoma and GS groups, all OCT parameters had an AUC >0.81 except the disc area parameter. Especially, average NFLT had the highest AUC of 0.94 in the OCT parameters. CONCLUSIONS: FDT, SWAP, flicker perimetry, and OCT are all useful methods for discriminating between healthy eyes and eyes with early glaucoma. Among all 10 OCT parameters, NFLT has the highest sensitivity for detecting early glaucomatous changes in GS patients. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/19225357/Detectability_of_glaucomatous_changes_using_SAP_FDT_flicker_perimetry_and_OCT_ L2 - http://dx.doi.org/10.1097/IJG.0b013e318179f7ca DB - PRIME DP - Unbound Medicine ER -