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No association between hip geometry and four common polymorphisms associated with fracture: the Danish osteoporosis prevention study.
Calcif Tissue Int. 2009 Apr; 84(4):276-85.CT

Abstract

Both osteoporosis and hip geometry are independently associated with fracture risk. There is a significant genetic contribution to the risk of osteoporosis, and evidence provided by twin studies has suggested that hip geometry may also in part be genetically programmed. Polymorphisms in a number of genes, including those coding for methylene-tetrahydrofolate reductase (MTHFR c.677C > T), the purinergic P2X(7) receptor (Glu496Ala and Ile568Asn), and the low-density lipoprotein receptor-related protein 5 (LRP5 exon 9 [c.266A > G]), have been associated with an increased fracture incidence and/or reduced bone mineral density (BMD). The aim of the present study was to test whether these polymorphisms influence hip structural geometry in perimenopausal women. The four polymorphisms were genotyped in 800 healthy recently perimenopausal women never using hormone replacement therapy. BMD of the femoral neck was measured using a Hologic QDR-2000 densitometer and femoral neck axis length, neck width, neck shaft angle, and femoral head diameter were measured from the screen images. Genotype frequencies were compatible with Hardy-Weinberg equilibrium. No significant differences between homozygotes for the minor allele and carriers of the common allele regarding parameters of hip geometry were demonstrated. According to the anthropometric characteristics of the subjects, only body height in the MTHFR TT genotype group was significantly different from the combined CT/CC genotype group (P < 0.05). The geometric dimensions of the proximal femur in perimenopausal women are not associated with the MTHFR c.677C > T, P2X(7) (Glu496Ala), P2X(7) (Ile568Asn), and LRP5 exon 9 (c.266A > G) polymorphisms.

Authors+Show Affiliations

Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, 5000, Odense C, Denmark. hra@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19225709

Citation

Nissen, N, et al. "No Association Between Hip Geometry and Four Common Polymorphisms Associated With Fracture: the Danish Osteoporosis Prevention Study." Calcified Tissue International, vol. 84, no. 4, 2009, pp. 276-85.
Nissen N, Madsen JS, Bladbjerg EM, et al. No association between hip geometry and four common polymorphisms associated with fracture: the Danish osteoporosis prevention study. Calcif Tissue Int. 2009;84(4):276-85.
Nissen, N., Madsen, J. S., Bladbjerg, E. M., Beck Jensen, J. E., Jørgensen, N. R., Langdahl, B., Abrahamsen, B., & Brixen, K. (2009). No association between hip geometry and four common polymorphisms associated with fracture: the Danish osteoporosis prevention study. Calcified Tissue International, 84(4), 276-85. https://doi.org/10.1007/s00223-009-9219-9
Nissen N, et al. No Association Between Hip Geometry and Four Common Polymorphisms Associated With Fracture: the Danish Osteoporosis Prevention Study. Calcif Tissue Int. 2009;84(4):276-85. PubMed PMID: 19225709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No association between hip geometry and four common polymorphisms associated with fracture: the Danish osteoporosis prevention study. AU - Nissen,N, AU - Madsen,J S, AU - Bladbjerg,E M, AU - Beck Jensen,J E, AU - Jørgensen,N R, AU - Langdahl,B, AU - Abrahamsen,B, AU - Brixen,K, Y1 - 2009/02/19/ PY - 2008/06/22/received PY - 2009/01/16/accepted PY - 2009/2/20/entrez PY - 2009/2/20/pubmed PY - 2009/6/9/medline SP - 276 EP - 85 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 84 IS - 4 N2 - Both osteoporosis and hip geometry are independently associated with fracture risk. There is a significant genetic contribution to the risk of osteoporosis, and evidence provided by twin studies has suggested that hip geometry may also in part be genetically programmed. Polymorphisms in a number of genes, including those coding for methylene-tetrahydrofolate reductase (MTHFR c.677C > T), the purinergic P2X(7) receptor (Glu496Ala and Ile568Asn), and the low-density lipoprotein receptor-related protein 5 (LRP5 exon 9 [c.266A > G]), have been associated with an increased fracture incidence and/or reduced bone mineral density (BMD). The aim of the present study was to test whether these polymorphisms influence hip structural geometry in perimenopausal women. The four polymorphisms were genotyped in 800 healthy recently perimenopausal women never using hormone replacement therapy. BMD of the femoral neck was measured using a Hologic QDR-2000 densitometer and femoral neck axis length, neck width, neck shaft angle, and femoral head diameter were measured from the screen images. Genotype frequencies were compatible with Hardy-Weinberg equilibrium. No significant differences between homozygotes for the minor allele and carriers of the common allele regarding parameters of hip geometry were demonstrated. According to the anthropometric characteristics of the subjects, only body height in the MTHFR TT genotype group was significantly different from the combined CT/CC genotype group (P < 0.05). The geometric dimensions of the proximal femur in perimenopausal women are not associated with the MTHFR c.677C > T, P2X(7) (Glu496Ala), P2X(7) (Ile568Asn), and LRP5 exon 9 (c.266A > G) polymorphisms. SN - 1432-0827 UR - https://www.unboundmedicine.com/medline/citation/19225709/No_association_between_hip_geometry_and_four_common_polymorphisms_associated_with_fracture:_the_Danish_osteoporosis_prevention_study_ L2 - https://dx.doi.org/10.1007/s00223-009-9219-9 DB - PRIME DP - Unbound Medicine ER -