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Passive smoke exposure induces oxidative damage in brains of rat pups: Protective role of diphenyl diselenide.
Inhal Toxicol. 2009 Aug; 21(10):868-74.IT

Abstract

The protective effect of diphenyl diselenide, (PhSe)(2), on oxidative stress induced by cigarette smoke exposure in brains of rat pups was evaluated. Animals were exposed to passive cigarette smoke (15 min/day) in two different experimental protocols: P1 (1, 2, and 3 cigarettes) and P2 (4, 5, and 6 cigarettes) for 3 weeks. Before each period of smoke exposure, animals received an oral administration of (PhSe)(2) (0.5 mg/kg). A number of toxicological parameters in the brain were examined, such as lipid peroxidation, delta-aminolevulinate dehydratase (delta-ALA-D) activity, and components of enzymatic (superoxide dismutase and catalase activities) and non-enzymatic antioxidant defenses (ascorbic acid and non-protein thiol levels). In P1, smoke exposure induced an inhibition of catalase activity and an increase of ascorbic acid levels. (PhSe)(2) treatment was able to protect catalase activity but not ascorbic acid levels. In P2, an augmentation of lipid peroxidation, a reduction of enzymatic and non-enzymatic antioxidant status, and an inhibition of delta-ALA-D activity caused by smoke exposure were found. (PhSe)(2) protected the brains of rat pups against oxidative damage induced by smoke exposure. The results are consistent with the antioxidant effect of (PhSe)(2) demonstrated by the reduction of oxidative changes caused by smoke exposure in the brains of pups.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19225963

Citation

Stangherlin, Eluza Curte, et al. "Passive Smoke Exposure Induces Oxidative Damage in Brains of Rat Pups: Protective Role of Diphenyl Diselenide." Inhalation Toxicology, vol. 21, no. 10, 2009, pp. 868-74.
Stangherlin EC, Luchese C, Ardais AP, et al. Passive smoke exposure induces oxidative damage in brains of rat pups: Protective role of diphenyl diselenide. Inhal Toxicol. 2009;21(10):868-74.
Stangherlin, E. C., Luchese, C., Ardais, A. P., & Nogueira, C. W. (2009). Passive smoke exposure induces oxidative damage in brains of rat pups: Protective role of diphenyl diselenide. Inhalation Toxicology, 21(10), 868-74. https://doi.org/10.1080/08958370802526881
Stangherlin EC, et al. Passive Smoke Exposure Induces Oxidative Damage in Brains of Rat Pups: Protective Role of Diphenyl Diselenide. Inhal Toxicol. 2009;21(10):868-74. PubMed PMID: 19225963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Passive smoke exposure induces oxidative damage in brains of rat pups: Protective role of diphenyl diselenide. AU - Stangherlin,Eluza Curte, AU - Luchese,Cristiane, AU - Ardais,Ana Paula, AU - Nogueira,Cristina Wayne, PY - 2009/2/20/entrez PY - 2009/2/20/pubmed PY - 2009/12/31/medline SP - 868 EP - 74 JF - Inhalation toxicology JO - Inhal Toxicol VL - 21 IS - 10 N2 - The protective effect of diphenyl diselenide, (PhSe)(2), on oxidative stress induced by cigarette smoke exposure in brains of rat pups was evaluated. Animals were exposed to passive cigarette smoke (15 min/day) in two different experimental protocols: P1 (1, 2, and 3 cigarettes) and P2 (4, 5, and 6 cigarettes) for 3 weeks. Before each period of smoke exposure, animals received an oral administration of (PhSe)(2) (0.5 mg/kg). A number of toxicological parameters in the brain were examined, such as lipid peroxidation, delta-aminolevulinate dehydratase (delta-ALA-D) activity, and components of enzymatic (superoxide dismutase and catalase activities) and non-enzymatic antioxidant defenses (ascorbic acid and non-protein thiol levels). In P1, smoke exposure induced an inhibition of catalase activity and an increase of ascorbic acid levels. (PhSe)(2) treatment was able to protect catalase activity but not ascorbic acid levels. In P2, an augmentation of lipid peroxidation, a reduction of enzymatic and non-enzymatic antioxidant status, and an inhibition of delta-ALA-D activity caused by smoke exposure were found. (PhSe)(2) protected the brains of rat pups against oxidative damage induced by smoke exposure. The results are consistent with the antioxidant effect of (PhSe)(2) demonstrated by the reduction of oxidative changes caused by smoke exposure in the brains of pups. SN - 1091-7691 UR - https://www.unboundmedicine.com/medline/citation/19225963/Passive_smoke_exposure_induces_oxidative_damage_in_brains_of_rat_pups:_Protective_role_of_diphenyl_diselenide_ L2 - https://www.tandfonline.com/doi/full/10.1080/08958370802526881 DB - PRIME DP - Unbound Medicine ER -