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B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption.
J Intern Med. 2009 May; 265(5):604-15.JI

Abstract

OBJECTIVE

To assess the utility of B-type natriuretic peptide (BNP) and C-terminal-pro-endothelin-1 (CT-proET-1) to predict a severely impaired peak oxygen consumption (peak VO(2), < 14 mL kg(-1) min(-1)) in patients referred for cardiopulmonary exercise testing.

DESIGN

Cross-sectional study.

SETTING

Tertiary care center.

METHODS

Peak VO(2), BNP and CT-proET-1 were assessed in 141 consecutive patients referred for cardiopulmonary exercise testing.

RESULTS

B-type natriuretic peptide [median (interquartile range) 48 (38-319) vs. 33 (15-86) pg mL(-1); P = 0.002] and CT-proET-1 [87 (76-95) vs. 60 (52-74) pmol L(-1); P < 0.001] were higher in patients with a peak VO(2) < 14 mL kg(-1) min(-1) (n = 30) than in those with a peak VO(2) > or = 14 mL kg(-1) min(-1) (n = 111). CT-pro-ET-1 had a higher area under the receiver-operator-characteristics curve (AUC) to predict a peak VO(2) < 14 mL kg(-1) min(-1) than BNP (0.79 vs. 0.68; P = 0.04). The optimal BNP cut-off of 37.2 pg mL(-1) had a sensitivity of 80% and a specificity of 56%. The optimal CT-proET-1 cut-off of 74.4 pmol L(-1) had a sensitivity of 80% and specificity of 76%. A five-item score composed of body mass index, diabetes, forced expiratory volume within the first second, alveolo-arterial oxygen pressure difference, and BNP had an AUC of 0.88 to predict a peak VO(2) < 14 mL kg(-1) min(-1). Adding CT-proET-1 to the score resulted in an AUC of 0.92.

CONCLUSIONS

C-terminal-pro-endothelin-1 is superior to BNP for the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) in patients referred for CPET. A score incorporating body mass index, diabetes status, spirometry, blood gases, BNP and CT-proET-1 improves the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) based on single biomarkers.

Authors+Show Affiliations

Division of Cardiology, University Hospital Basel, Basel, Switzerland. micha.maeder@bluewin.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19226375

Citation

Maeder, M T., et al. "B-type Natriuretic Peptide and C-terminal-pro-endothelin-1 for the Prediction of Severely Impaired Peak Oxygen Consumption." Journal of Internal Medicine, vol. 265, no. 5, 2009, pp. 604-15.
Maeder MT, Brutsche MH, Staub D, et al. B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption. J Intern Med. 2009;265(5):604-15.
Maeder, M. T., Brutsche, M. H., Staub, D., Morgenthaler, N. G., Bergmann, A., Noveanu, M., Laule, K., Breidthardt, T., Christ, A., Klima, T., Reichlin, T., Potocki, M., & Mueller, C. (2009). B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption. Journal of Internal Medicine, 265(5), 604-15. https://doi.org/10.1111/j.1365-2796.2009.02071.x
Maeder MT, et al. B-type Natriuretic Peptide and C-terminal-pro-endothelin-1 for the Prediction of Severely Impaired Peak Oxygen Consumption. J Intern Med. 2009;265(5):604-15. PubMed PMID: 19226375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption. AU - Maeder,M T, AU - Brutsche,M H, AU - Staub,D, AU - Morgenthaler,N G, AU - Bergmann,A, AU - Noveanu,M, AU - Laule,K, AU - Breidthardt,T, AU - Christ,A, AU - Klima,T, AU - Reichlin,T, AU - Potocki,M, AU - Mueller,C, Y1 - 2009/02/16/ PY - 2009/2/20/entrez PY - 2009/2/20/pubmed PY - 2009/5/23/medline SP - 604 EP - 15 JF - Journal of internal medicine JO - J Intern Med VL - 265 IS - 5 N2 - OBJECTIVE: To assess the utility of B-type natriuretic peptide (BNP) and C-terminal-pro-endothelin-1 (CT-proET-1) to predict a severely impaired peak oxygen consumption (peak VO(2), < 14 mL kg(-1) min(-1)) in patients referred for cardiopulmonary exercise testing. DESIGN: Cross-sectional study. SETTING: Tertiary care center. METHODS: Peak VO(2), BNP and CT-proET-1 were assessed in 141 consecutive patients referred for cardiopulmonary exercise testing. RESULTS: B-type natriuretic peptide [median (interquartile range) 48 (38-319) vs. 33 (15-86) pg mL(-1); P = 0.002] and CT-proET-1 [87 (76-95) vs. 60 (52-74) pmol L(-1); P < 0.001] were higher in patients with a peak VO(2) < 14 mL kg(-1) min(-1) (n = 30) than in those with a peak VO(2) > or = 14 mL kg(-1) min(-1) (n = 111). CT-pro-ET-1 had a higher area under the receiver-operator-characteristics curve (AUC) to predict a peak VO(2) < 14 mL kg(-1) min(-1) than BNP (0.79 vs. 0.68; P = 0.04). The optimal BNP cut-off of 37.2 pg mL(-1) had a sensitivity of 80% and a specificity of 56%. The optimal CT-proET-1 cut-off of 74.4 pmol L(-1) had a sensitivity of 80% and specificity of 76%. A five-item score composed of body mass index, diabetes, forced expiratory volume within the first second, alveolo-arterial oxygen pressure difference, and BNP had an AUC of 0.88 to predict a peak VO(2) < 14 mL kg(-1) min(-1). Adding CT-proET-1 to the score resulted in an AUC of 0.92. CONCLUSIONS: C-terminal-pro-endothelin-1 is superior to BNP for the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) in patients referred for CPET. A score incorporating body mass index, diabetes status, spirometry, blood gases, BNP and CT-proET-1 improves the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) based on single biomarkers. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/19226375/B_type_natriuretic_peptide_and_C_terminal_pro_endothelin_1_for_the_prediction_of_severely_impaired_peak_oxygen_consumption_ L2 - https://doi.org/10.1111/j.1365-2796.2009.02071.x DB - PRIME DP - Unbound Medicine ER -