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Effects of a 1,450 nm diode laser on facial sebum excretion.
Lasers Surg Med 2009; 41(2):110-5LS

Abstract

BACKGROUND AND OBJECTIVE

Laser therapy with a 1,450 nm diode laser is a clinically effective treatment for acne vulgaris, although the mechanism of action is unknown. To investigate this, we conducted a small, prospective, controlled clinical trial to assess this laser's effects on the facial sebum excretion rate (SER).

MATERIALS AND METHODS

Fourteen healthy volunteers without active acne were enrolled in this study and received three laser treatments on test areas of the nose and forehead. Nine subjects completed the treatment regimen and were available for follow-up. SER was measured with Sebumeter prior to the first treatment, and at 1 week and 1 month after the third treatment. Photographs were taken and subjective assessment of skin oiliness and pore size determined by questionnaires at 1 month follow-up.

RESULTS

No significant reduction in SER was observed comparing treated with control on all treatment sites (P>0.05) on the nose. Reduction in the absolute SER was observed for both test and control sites on the forehead, reaching significance on the treatment site (P = 0.04) and marginal significance on the control site (P = 0.08).

CONCLUSION

While our study was designed to detect only large changes in SER, we conclude that three 1,450 nm laser treatment sessions did not cause marked changes in SER compared to the control (i.e., >44%). Thus, major destruction of sebaceous glands as a result of this treatment is unlikely. However, reduced sebum production was observed on both treatment and control sides at 1 month. Therefore alternative mechanisms should also be considered to explain the clinical efficacy of this treatment for acne vulgaris.

Authors+Show Affiliations

Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Harvard Medical School, Boston, Massachusetts 02114, USA. hlaubach@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19226569

Citation

Laubach, Hans-Joachim, et al. "Effects of a 1,450 Nm Diode Laser On Facial Sebum Excretion." Lasers in Surgery and Medicine, vol. 41, no. 2, 2009, pp. 110-5.
Laubach HJ, Astner S, Watanabe K, et al. Effects of a 1,450 nm diode laser on facial sebum excretion. Lasers Surg Med. 2009;41(2):110-5.
Laubach, H. J., Astner, S., Watanabe, K., Clifford, J., Rius-Diaz, F., Zurakowski, D., & Manstein, D. (2009). Effects of a 1,450 nm diode laser on facial sebum excretion. Lasers in Surgery and Medicine, 41(2), pp. 110-5. doi:10.1002/lsm.20672.
Laubach HJ, et al. Effects of a 1,450 Nm Diode Laser On Facial Sebum Excretion. Lasers Surg Med. 2009;41(2):110-5. PubMed PMID: 19226569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a 1,450 nm diode laser on facial sebum excretion. AU - Laubach,Hans-Joachim, AU - Astner,Susanne, AU - Watanabe,Kanna, AU - Clifford,Joan, AU - Rius-Diaz,Francisca, AU - Zurakowski,David, AU - Manstein,Dieter, PY - 2009/2/20/entrez PY - 2009/2/20/pubmed PY - 2009/7/29/medline SP - 110 EP - 5 JF - Lasers in surgery and medicine JO - Lasers Surg Med VL - 41 IS - 2 N2 - BACKGROUND AND OBJECTIVE: Laser therapy with a 1,450 nm diode laser is a clinically effective treatment for acne vulgaris, although the mechanism of action is unknown. To investigate this, we conducted a small, prospective, controlled clinical trial to assess this laser's effects on the facial sebum excretion rate (SER). MATERIALS AND METHODS: Fourteen healthy volunteers without active acne were enrolled in this study and received three laser treatments on test areas of the nose and forehead. Nine subjects completed the treatment regimen and were available for follow-up. SER was measured with Sebumeter prior to the first treatment, and at 1 week and 1 month after the third treatment. Photographs were taken and subjective assessment of skin oiliness and pore size determined by questionnaires at 1 month follow-up. RESULTS: No significant reduction in SER was observed comparing treated with control on all treatment sites (P>0.05) on the nose. Reduction in the absolute SER was observed for both test and control sites on the forehead, reaching significance on the treatment site (P = 0.04) and marginal significance on the control site (P = 0.08). CONCLUSION: While our study was designed to detect only large changes in SER, we conclude that three 1,450 nm laser treatment sessions did not cause marked changes in SER compared to the control (i.e., >44%). Thus, major destruction of sebaceous glands as a result of this treatment is unlikely. However, reduced sebum production was observed on both treatment and control sides at 1 month. Therefore alternative mechanisms should also be considered to explain the clinical efficacy of this treatment for acne vulgaris. SN - 1096-9101 UR - https://www.unboundmedicine.com/medline/citation/19226569/Effects_of_a_1450_nm_diode_laser_on_facial_sebum_excretion_ L2 - https://doi.org/10.1002/lsm.20672 DB - PRIME DP - Unbound Medicine ER -