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Bioactive cycloartane-type triterpene glycosides from Astragalus elongatus.
Z Naturforsch C J Biosci. 2008 Nov-Dec; 63(11-12):813-20.ZN

Abstract

Together with two known cycloartane-type glycosides, askendosides D (3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-6-O-beta-xylopyranosyl-cycloastragenol, 2) and G (3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-16-O-beta-glucopyranosyl-3 beta,6 alpha,16 beta,24(R),25-pentahydroxycycloartane, 3), also a new monodesmosidic cycloartane-type glycoside, elongatoside (1), was isolated from the roots of Astragalus elongatus and identified as 3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-cycloastragenol. All structures were unambiguously determined by means of spectroscopic and spectrometric methods (1D and 2D NMR, ESI-MS). The isolated compounds were tested for the inhibition of proliferation and ICAM-1 expression in vitro using the human microvascular endothelial cell line (HMEC-1). 1 showed weak activity in the ICAM-1 assay.

Authors+Show Affiliations

Caliş I
Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey.
Barbic M
No affiliation info available
Jürgenliemk G
No affiliation info available

MeSH

Astragalus PlantCell DivisionCell SurvivalEndothelium, VascularGlycosidesHumansIntercellular Adhesion Molecule-1Magnetic Resonance SpectroscopyMicrocirculationModels, MolecularMolecular ConformationPlant ExtractsPlant RootsTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19227828

Citation

Caliş, Ihsan, et al. "Bioactive Cycloartane-type Triterpene Glycosides From Astragalus Elongatus." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 63, no. 11-12, 2008, pp. 813-20.
Caliş I, Barbic M, Jürgenliemk G. Bioactive cycloartane-type triterpene glycosides from Astragalus elongatus. Z Naturforsch C J Biosci. 2008;63(11-12):813-20.
Caliş, I., Barbic, M., & Jürgenliemk, G. (2008). Bioactive cycloartane-type triterpene glycosides from Astragalus elongatus. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 63(11-12), 813-20.
Caliş I, Barbic M, Jürgenliemk G. Bioactive Cycloartane-type Triterpene Glycosides From Astragalus Elongatus. Z Naturforsch C J Biosci. 2008 Nov-Dec;63(11-12):813-20. PubMed PMID: 19227828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive cycloartane-type triterpene glycosides from Astragalus elongatus. AU - Caliş,Ihsan, AU - Barbic,Matej, AU - Jürgenliemk,Guido, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/4/28/medline SP - 813 EP - 20 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z Naturforsch C J Biosci VL - 63 IS - 11-12 N2 - Together with two known cycloartane-type glycosides, askendosides D (3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-6-O-beta-xylopyranosyl-cycloastragenol, 2) and G (3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-16-O-beta-glucopyranosyl-3 beta,6 alpha,16 beta,24(R),25-pentahydroxycycloartane, 3), also a new monodesmosidic cycloartane-type glycoside, elongatoside (1), was isolated from the roots of Astragalus elongatus and identified as 3-O-[alpha-arabinopyranosyl-(1-->2)-beta-xylopyranosyl]-cycloastragenol. All structures were unambiguously determined by means of spectroscopic and spectrometric methods (1D and 2D NMR, ESI-MS). The isolated compounds were tested for the inhibition of proliferation and ICAM-1 expression in vitro using the human microvascular endothelial cell line (HMEC-1). 1 showed weak activity in the ICAM-1 assay. SN - 0939-5075 UR - https://www.unboundmedicine.com/medline/citation/19227828/Bioactive_cycloartane_type_triterpene_glycosides_from_Astragalus_elongatus_ DB - PRIME DP - Unbound Medicine ER -