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Cannabidiol: a promising drug for neurodegenerative disorders?
CNS Neurosci Ther 2009; 15(1):65-75CN

Abstract

Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients experience in these diseases. A range of mutant genes and environmental toxins have been implicated in the cause of neurodegenerative disorders but the mechanism remains largely unknown. At present, inflammation, a common denominator among the diverse list of neurodegenerative diseases, has been implicated as a critical mechanism that is responsible for the progressive nature of neurodegeneration. Since, at present, there are few therapies for the wide range of neurodegenerative diseases, scientists are still in search of new therapeutic approaches to the problem. An early contribution of neuroprotective and antiinflammatory strategies for these disorders seems particularly desirable because isolated treatments cannot be effective. In this contest, marijuana derivatives have attracted special interest, although these compounds have always raised several practical and ethical problems for their potential abuse. Nevertheless, among Cannabis compounds, cannabidiol (CBD), which lacks any unwanted psychotropic effect, may represent a very promising agent with the highest prospect for therapeutic use.

Authors+Show Affiliations

Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Via D. Montesano 49, Naples, Italy. iuvone@unina.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19228180

Citation

Iuvone, Teresa, et al. "Cannabidiol: a Promising Drug for Neurodegenerative Disorders?" CNS Neuroscience & Therapeutics, vol. 15, no. 1, 2009, pp. 65-75.
Iuvone T, Esposito G, De Filippis D, et al. Cannabidiol: a promising drug for neurodegenerative disorders? CNS Neurosci Ther. 2009;15(1):65-75.
Iuvone, T., Esposito, G., De Filippis, D., Scuderi, C., & Steardo, L. (2009). Cannabidiol: a promising drug for neurodegenerative disorders? CNS Neuroscience & Therapeutics, 15(1), pp. 65-75. doi:10.1111/j.1755-5949.2008.00065.x.
Iuvone T, et al. Cannabidiol: a Promising Drug for Neurodegenerative Disorders. CNS Neurosci Ther. 2009;15(1):65-75. PubMed PMID: 19228180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol: a promising drug for neurodegenerative disorders? AU - Iuvone,Teresa, AU - Esposito,Giuseppe, AU - De Filippis,Daniele, AU - Scuderi,Caterina, AU - Steardo,Luca, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/4/16/medline SP - 65 EP - 75 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 15 IS - 1 N2 - Neurodegenerative diseases represent, nowadays, one of the main causes of death in the industrialized country. They are characterized by a loss of neurons in particular regions of the nervous system. It is believed that this nerve cell loss underlies the subsequent decline in cognitive and motor function that patients experience in these diseases. A range of mutant genes and environmental toxins have been implicated in the cause of neurodegenerative disorders but the mechanism remains largely unknown. At present, inflammation, a common denominator among the diverse list of neurodegenerative diseases, has been implicated as a critical mechanism that is responsible for the progressive nature of neurodegeneration. Since, at present, there are few therapies for the wide range of neurodegenerative diseases, scientists are still in search of new therapeutic approaches to the problem. An early contribution of neuroprotective and antiinflammatory strategies for these disorders seems particularly desirable because isolated treatments cannot be effective. In this contest, marijuana derivatives have attracted special interest, although these compounds have always raised several practical and ethical problems for their potential abuse. Nevertheless, among Cannabis compounds, cannabidiol (CBD), which lacks any unwanted psychotropic effect, may represent a very promising agent with the highest prospect for therapeutic use. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/19228180/abstract/Cannabidiol:_a_promising_drug_for_neurodegenerative_disorders L2 - https://doi.org/10.1111/j.1755-5949.2008.00065.x DB - PRIME DP - Unbound Medicine ER -