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Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
Methods Find Exp Clin Pharmacol. 2008 Nov; 30(9):691-6.MF

Abstract

Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain.

Authors+Show Affiliations

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia. mrs@medic.upm.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19229377

Citation

Sulaiman, Mohd Roslan, et al. "Antinociceptive and Antiinflammatory Activities of the Aqueous Extract of Trigonopleura Malayana Resin in Experimental Animal Models." Methods and Findings in Experimental and Clinical Pharmacology, vol. 30, no. 9, 2008, pp. 691-6.
Sulaiman MR, Zakaria ZA, Kamaruddin A, et al. Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Methods Find Exp Clin Pharmacol. 2008;30(9):691-6.
Sulaiman, M. R., Zakaria, Z. A., Kamaruddin, A., Meng, T. F., Ali, D. I., & Moin, S. (2008). Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Methods and Findings in Experimental and Clinical Pharmacology, 30(9), 691-6. https://doi.org/10.1358/mf.2008.30.9.1305824
Sulaiman MR, et al. Antinociceptive and Antiinflammatory Activities of the Aqueous Extract of Trigonopleura Malayana Resin in Experimental Animal Models. Methods Find Exp Clin Pharmacol. 2008;30(9):691-6. PubMed PMID: 19229377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. AU - Sulaiman,Mohd Roslan, AU - Zakaria,Zainul Amiruddin, AU - Kamaruddin,Anita, AU - Meng,Teoh Fei, AU - Ali,Daud Israf, AU - Moin,Saidi, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/6/10/medline SP - 691 EP - 6 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 30 IS - 9 N2 - Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/19229377/Antinociceptive_and_antiinflammatory_activities_of_the_aqueous_extract_of_Trigonopleura_malayana_resin_in_experimental_animal_models_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&amp;p_RefId=1305824 DB - PRIME DP - Unbound Medicine ER -