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Trafficking and differentiation of mesenchymal stem cells.
J Cell Biochem. 2009 Apr 15; 106(6):984-91.JC

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non-mesodermal cell lineages, including osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes, fibroblasts, myofibroblasts, epithelial cells, and neurons. MSCs reside primarily in the bone marrow, but also exist in other sites such as adipose tissue, peripheral blood, cord blood, liver, and fetal tissues. When stimulated by specific signals, these cells can be released from their niche in the bone marrow into circulation and recruited to the target tissues where they undergo in situ differentiation and contribute to tissue regeneration and homeostasis. Several characteristics of MSCs, such as the potential to differentiate into multiple lineages and the ability to be expanded ex vivo while retaining their original lineage differentiation commitment, make these cells very interesting targets for potential therapeutic use in regenerative medicine and tissue engineering. The feasibility for transplantation of primary or engineered MSCs as cell-based therapy has been demonstrated. In this review, we summarize the current knowledge on the signals that control trafficking and differentiation of MSCs.

Authors+Show Affiliations

The DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of MiamiJackson Memorial Medical Center, Miami, FL 33136, USA. ovelazquez@med.miami.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19229871

Citation

Liu, Zhao-Jun, et al. "Trafficking and Differentiation of Mesenchymal Stem Cells." Journal of Cellular Biochemistry, vol. 106, no. 6, 2009, pp. 984-91.
Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and differentiation of mesenchymal stem cells. J Cell Biochem. 2009;106(6):984-91.
Liu, Z. J., Zhuge, Y., & Velazquez, O. C. (2009). Trafficking and differentiation of mesenchymal stem cells. Journal of Cellular Biochemistry, 106(6), 984-91. https://doi.org/10.1002/jcb.22091
Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and Differentiation of Mesenchymal Stem Cells. J Cell Biochem. 2009 Apr 15;106(6):984-91. PubMed PMID: 19229871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trafficking and differentiation of mesenchymal stem cells. AU - Liu,Zhao-Jun, AU - Zhuge,Ying, AU - Velazquez,Omaida C, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/7/8/medline SP - 984 EP - 91 JF - Journal of cellular biochemistry JO - J. Cell. Biochem. VL - 106 IS - 6 N2 - Mesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non-mesodermal cell lineages, including osteocytes, adipocytes, chondrocytes, myocytes, cardiomyocytes, fibroblasts, myofibroblasts, epithelial cells, and neurons. MSCs reside primarily in the bone marrow, but also exist in other sites such as adipose tissue, peripheral blood, cord blood, liver, and fetal tissues. When stimulated by specific signals, these cells can be released from their niche in the bone marrow into circulation and recruited to the target tissues where they undergo in situ differentiation and contribute to tissue regeneration and homeostasis. Several characteristics of MSCs, such as the potential to differentiate into multiple lineages and the ability to be expanded ex vivo while retaining their original lineage differentiation commitment, make these cells very interesting targets for potential therapeutic use in regenerative medicine and tissue engineering. The feasibility for transplantation of primary or engineered MSCs as cell-based therapy has been demonstrated. In this review, we summarize the current knowledge on the signals that control trafficking and differentiation of MSCs. SN - 1097-4644 UR - https://www.unboundmedicine.com/medline/citation/19229871/Trafficking_and_differentiation_of_mesenchymal_stem_cells_ L2 - https://doi.org/10.1002/jcb.22091 DB - PRIME DP - Unbound Medicine ER -