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Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA.
World J Gastroenterol. 2009 Feb 21; 15(7):845-8.WJ

Abstract

AIM

To indirectly determine if tissue transglutaminase (tTG)-specific T cells play a crucial role in the propagation of celiac disease.

METHODS

Anti-deamidated gliadin peptide (DGP) and anti-tTG IgA and IgG were measured in the sera of celiac patients (both untreated and treated). The correlations were determined by Spearman's rank correlation test.

RESULTS

In celiac patients, we found a very significant correlation between the production of DGP IgA and IgG (r = 0.75), indicating a simultaneous and ongoing production of these two isotypes reminiscent of oral vaccination studies. However, there was far less association between the production of tTG IgA and tTG IgG in celiac patients (r = 0.52). While tTG IgA was significantly correlated with DGP IgA (r = 0.80) and DGP IgG (r = 0.67), there was a weak correlation between production of anti-tTG IgG and the production of anti-DGP IgA (r = 0.38) and anti-DGP IgG (r = 0.43).

CONCLUSION

These data demonstrate that the production of anti-tTG IgA is directly correlated to the production of anti-DGP IgG and IgA, whereas anti-tTG IgG is only weakly correlated. This result therefore supports the hapten-carrier theory that in well-established celiac patients anti-tTG IgA is produced by a set of B cells that are reacting against the complex of tTG-DGP in the absence of a tTG-specific T cell.

Authors+Show Affiliations

Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, United States.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19230045

Citation

Marietta, Eric V., et al. "Correlation Analysis of Celiac Sprue Tissue Transglutaminase and Deamidated Gliadin IgG/IgA." World Journal of Gastroenterology, vol. 15, no. 7, 2009, pp. 845-8.
Marietta EV, Rashtak S, Murray JA. Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA. World J Gastroenterol. 2009;15(7):845-8.
Marietta, E. V., Rashtak, S., & Murray, J. A. (2009). Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA. World Journal of Gastroenterology, 15(7), 845-8.
Marietta EV, Rashtak S, Murray JA. Correlation Analysis of Celiac Sprue Tissue Transglutaminase and Deamidated Gliadin IgG/IgA. World J Gastroenterol. 2009 Feb 21;15(7):845-8. PubMed PMID: 19230045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA. AU - Marietta,Eric V, AU - Rashtak,Shadi, AU - Murray,Joseph A, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/5/21/medline SP - 845 EP - 8 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 15 IS - 7 N2 - AIM: To indirectly determine if tissue transglutaminase (tTG)-specific T cells play a crucial role in the propagation of celiac disease. METHODS: Anti-deamidated gliadin peptide (DGP) and anti-tTG IgA and IgG were measured in the sera of celiac patients (both untreated and treated). The correlations were determined by Spearman's rank correlation test. RESULTS: In celiac patients, we found a very significant correlation between the production of DGP IgA and IgG (r = 0.75), indicating a simultaneous and ongoing production of these two isotypes reminiscent of oral vaccination studies. However, there was far less association between the production of tTG IgA and tTG IgG in celiac patients (r = 0.52). While tTG IgA was significantly correlated with DGP IgA (r = 0.80) and DGP IgG (r = 0.67), there was a weak correlation between production of anti-tTG IgG and the production of anti-DGP IgA (r = 0.38) and anti-DGP IgG (r = 0.43). CONCLUSION: These data demonstrate that the production of anti-tTG IgA is directly correlated to the production of anti-DGP IgG and IgA, whereas anti-tTG IgG is only weakly correlated. This result therefore supports the hapten-carrier theory that in well-established celiac patients anti-tTG IgA is produced by a set of B cells that are reacting against the complex of tTG-DGP in the absence of a tTG-specific T cell. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/19230045/Correlation_analysis_of_celiac_sprue_tissue_transglutaminase_and_deamidated_gliadin_IgG/IgA_ L2 - http://www.wjgnet.com/1007-9327/full/v15/i7/845.htm DB - PRIME DP - Unbound Medicine ER -