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Acute coronary syndrome (ACS) registry--leading the charge for National Cardiovascular Disease (NCVD) Database.
Med J Malaysia. 2008 Sep; 63 Suppl C:29-36.MJ

Abstract

Coronary artery disease is one of the most rampant non-communicable diseases in the world. It begins indolently as a fatty streak in the lining of the artery that soon progresses to narrow the coronary arteries and impair myocardial perfusion. Often the atherosclerotic plaque ruptures and causes sudden thrombotic occlusion and acute ST-elevation myocardial infarction (STEMI), non-ST-elevation MI (NSTEMI) or unstable angina (UA). This phenomenon is called acute coronary syndrome (ACS) and is the leading cause of death not only in Malaysia but also globally. In order for us to tackle this threat to the health of our nation we must arm ourselves with reliable and accurate information to assess current burden of disease resources available and success of current strategies. The acute coronary syndrome (ACS) registry is the flagship of the National Cardiovascular Disease Database (NCVD) and is the result of the dedicated and untiring efforts of doctors and nurses in both public and private medical institutions and hospitals around the country, ably guided and supported by the National Heart Association, the National Heart Foundation, the Clinical Research Centre and the Ministry of Health of Malaysia. Analyses of data collected throughout 2006 from 3422 patients with ACS admitted to the 12 tertiary cardiac centres and general hospitals spanning nine states in Malaysia in this first report has already revealed surprising results. Mean age of patients was 59 years while the most consistent risk factor for STEMI was active smoking. Utilization of medications was high generally. Thirty-day mortality for STEMI was 11%, for NSTEMI 8% and UA 4%. Thrombolysis (for STEMI only) reduced in-hospital and 30-day mortality by nearly 50%. Percutaneous coronary intervention or PCI also reduced 30-day mortality for patients with non-ST elevation MI and unstable angina. The strongest determinants of mortality appears to be Killip Class and age of the patient. Fewer women received thrombolysis or underwent PCI on same admission although women make up 25% of the cohort.

Authors+Show Affiliations

International Medical University, No 126, Jalan 19/155B, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19230244

Citation

Chin, S P., et al. "Acute Coronary Syndrome (ACS) Registry--leading the Charge for National Cardiovascular Disease (NCVD) Database." The Medical Journal of Malaysia, vol. 63 Suppl C, 2008, pp. 29-36.
Chin SP, Jeyaindran S, Azhari R, et al. Acute coronary syndrome (ACS) registry--leading the charge for National Cardiovascular Disease (NCVD) Database. Med J Malaysia. 2008;63 Suppl C:29-36.
Chin, S. P., Jeyaindran, S., Azhari, R., Wan Azman, W. A., Omar, I., Robaayah, Z., & Sim, K. H. (2008). Acute coronary syndrome (ACS) registry--leading the charge for National Cardiovascular Disease (NCVD) Database. The Medical Journal of Malaysia, 63 Suppl C, 29-36.
Chin SP, et al. Acute Coronary Syndrome (ACS) Registry--leading the Charge for National Cardiovascular Disease (NCVD) Database. Med J Malaysia. 2008;63 Suppl C:29-36. PubMed PMID: 19230244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute coronary syndrome (ACS) registry--leading the charge for National Cardiovascular Disease (NCVD) Database. AU - Chin,S P, AU - Jeyaindran,S, AU - Azhari,R, AU - Wan Azman,W A, AU - Omar,I, AU - Robaayah,Z, AU - Sim,K H, PY - 2009/2/21/entrez PY - 2009/2/21/pubmed PY - 2009/3/19/medline SP - 29 EP - 36 JF - The Medical journal of Malaysia JO - Med. J. Malaysia VL - 63 Suppl C N2 - Coronary artery disease is one of the most rampant non-communicable diseases in the world. It begins indolently as a fatty streak in the lining of the artery that soon progresses to narrow the coronary arteries and impair myocardial perfusion. Often the atherosclerotic plaque ruptures and causes sudden thrombotic occlusion and acute ST-elevation myocardial infarction (STEMI), non-ST-elevation MI (NSTEMI) or unstable angina (UA). This phenomenon is called acute coronary syndrome (ACS) and is the leading cause of death not only in Malaysia but also globally. In order for us to tackle this threat to the health of our nation we must arm ourselves with reliable and accurate information to assess current burden of disease resources available and success of current strategies. The acute coronary syndrome (ACS) registry is the flagship of the National Cardiovascular Disease Database (NCVD) and is the result of the dedicated and untiring efforts of doctors and nurses in both public and private medical institutions and hospitals around the country, ably guided and supported by the National Heart Association, the National Heart Foundation, the Clinical Research Centre and the Ministry of Health of Malaysia. Analyses of data collected throughout 2006 from 3422 patients with ACS admitted to the 12 tertiary cardiac centres and general hospitals spanning nine states in Malaysia in this first report has already revealed surprising results. Mean age of patients was 59 years while the most consistent risk factor for STEMI was active smoking. Utilization of medications was high generally. Thirty-day mortality for STEMI was 11%, for NSTEMI 8% and UA 4%. Thrombolysis (for STEMI only) reduced in-hospital and 30-day mortality by nearly 50%. Percutaneous coronary intervention or PCI also reduced 30-day mortality for patients with non-ST elevation MI and unstable angina. The strongest determinants of mortality appears to be Killip Class and age of the patient. Fewer women received thrombolysis or underwent PCI on same admission although women make up 25% of the cohort. SN - 0300-5283 UR - https://www.unboundmedicine.com/medline/citation/19230244/Acute_coronary_syndrome__ACS__registry__leading_the_charge_for_National_Cardiovascular_Disease__NCVD__Database_ L2 - http://www.diseaseinfosearch.org/result/1315 DB - PRIME DP - Unbound Medicine ER -