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Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder.

Abstract

Affective impairment is observed in children and adolescents with attention-deficit hyperactivity disorder (ADHD). Low levels of long-chain polyunsaturated fatty acids (LC-PUFA), specifically omega-3 (omega-3) fatty acids in blood measures have been linked to a range of behavioural and mood disorders including ADHD. However, nothing is known about the relationship between omega-3 and brain function in children with ADHD. In the current study, 20 adolescent boys with ADHD were assessed for total lipid fractions in red blood cells and their event-related potential (ERP) response to the presentation of facial expressions of happiness, sadness and fearfulness. The results supported the hypothesis of a positive association between eicosapentaenoic acid (EPA) and a cognitive bias in orientation to overt expressions of happiness over both sad and fearful faces as indexed by midline frontal P300 amplitude. Additional exploratory analyses revealed a positive association between levels of docosahexaenoic acid (DHA) and the right temporal N170 amplitude in response to covert expressions of fear. The arachidonic (AA)/DHA ratio was negatively associated with the right temporal N170 amplitude also to covert expressions of fear. These findings indicate that EPA and DHA may be involved in distinct aspects of affect processing in ADHD and have implications for understanding currently inconsistent findings in the literature on EFA supplementation in ADHD and depression.

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  • Authors+Show Affiliations

    ,

    Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK. Rachel.gow@iop.kcl.ac.uk

    , , , , , , , ,

    Source

    MeSH

    Adolescent
    Arachidonic Acid
    Attention Deficit Disorder with Hyperactivity
    Brain
    Child
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Electroencephalography
    Emotions
    Erythrocytes
    Evoked Potentials
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Humans
    Male

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19230637

    Citation

    Gow, Rachel V., et al. "Total Red Blood Cell Concentrations of Omega-3 Fatty Acids Are Associated With Emotion-elicited Neural Activity in Adolescent Boys With Attention-deficit Hyperactivity Disorder." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 80, no. 2-3, 2009, pp. 151-6.
    Gow RV, Matsudaira T, Taylor E, et al. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2009;80(2-3):151-6.
    Gow, R. V., Matsudaira, T., Taylor, E., Rubia, K., Crawford, M., Ghebremeskel, K., ... Sumich, A. (2009). Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 80(2-3), pp. 151-6. doi:10.1016/j.plefa.2008.12.007.
    Gow RV, et al. Total Red Blood Cell Concentrations of Omega-3 Fatty Acids Are Associated With Emotion-elicited Neural Activity in Adolescent Boys With Attention-deficit Hyperactivity Disorder. Prostaglandins Leukot Essent Fatty Acids. 2009;80(2-3):151-6. PubMed PMID: 19230637.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. AU - Gow,Rachel V, AU - Matsudaira,Toshiko, AU - Taylor,Eric, AU - Rubia,Katya, AU - Crawford,Michael, AU - Ghebremeskel,Kebreab, AU - Ibrahimovic,Almira, AU - Vallée-Tourangeau,Frédéric, AU - Williams,Leanne M, AU - Sumich,Alexander, Y1 - 2009/02/20/ PY - 2008/11/17/received PY - 2008/12/14/revised PY - 2008/12/30/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/7/1/medline SP - 151 EP - 6 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 80 IS - 2-3 N2 - Affective impairment is observed in children and adolescents with attention-deficit hyperactivity disorder (ADHD). Low levels of long-chain polyunsaturated fatty acids (LC-PUFA), specifically omega-3 (omega-3) fatty acids in blood measures have been linked to a range of behavioural and mood disorders including ADHD. However, nothing is known about the relationship between omega-3 and brain function in children with ADHD. In the current study, 20 adolescent boys with ADHD were assessed for total lipid fractions in red blood cells and their event-related potential (ERP) response to the presentation of facial expressions of happiness, sadness and fearfulness. The results supported the hypothesis of a positive association between eicosapentaenoic acid (EPA) and a cognitive bias in orientation to overt expressions of happiness over both sad and fearful faces as indexed by midline frontal P300 amplitude. Additional exploratory analyses revealed a positive association between levels of docosahexaenoic acid (DHA) and the right temporal N170 amplitude in response to covert expressions of fear. The arachidonic (AA)/DHA ratio was negatively associated with the right temporal N170 amplitude also to covert expressions of fear. These findings indicate that EPA and DHA may be involved in distinct aspects of affect processing in ADHD and have implications for understanding currently inconsistent findings in the literature on EFA supplementation in ADHD and depression. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/19230637/Total_red_blood_cell_concentrations_of_omega_3_fatty_acids_are_associated_with_emotion_elicited_neural_activity_in_adolescent_boys_with_attention_deficit_hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(09)00002-7 DB - PRIME DP - Unbound Medicine ER -