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Outbreak of CTX-M-15-producing Klebsiella pneumoniae in the intensive care unit of a French hospital.
Microb Drug Resist. 2009 Mar; 15(1):47-54.MD

Abstract

The CTX-M-15 extended spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were identified in 36 patients hospitalized from December 2006 to September 2007 in the medical intensive care unit (ICU) of the Bicêtre hospital, South Paris, France. The incidence of colonization and/or infection was 4.8%. Eighty-nine percent of the ESBL-producing K. pneumoniae isolates were acquired in the ICU, and only 8.3% of the patients were infected. Pulsed field gel electrophoresis (PFGE) analysis of the isolates showed that 32 isolates were clonally related and contained a 160-kb plasmid carrying the bla(CTX-M-15), bla(OXA-1), bla(TEM-1), and aac6'-Ib-cr genes. CTX-M-15-producing Escherichia coli isolates collected in the ward during the same period of time contained distinct plasmids and were not clonally related. This study highlights the possible occurrence of outbreaks due to CTX-M-producing K. pneumoniae within hospital settings, whereas CTX-Ms are mostly reported in E. coli in community-acquired infections.

Authors+Show Affiliations

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19231938

Citation

Carrër, Amelie, et al. "Outbreak of CTX-M-15-producing Klebsiella Pneumoniae in the Intensive Care Unit of a French Hospital." Microbial Drug Resistance (Larchmont, N.Y.), vol. 15, no. 1, 2009, pp. 47-54.
Carrër A, Lassel L, Fortineau N, et al. Outbreak of CTX-M-15-producing Klebsiella pneumoniae in the intensive care unit of a French hospital. Microb Drug Resist. 2009;15(1):47-54.
Carrër, A., Lassel, L., Fortineau, N., Mansouri, M., Anguel, N., Richard, C., & Nordmann, P. (2009). Outbreak of CTX-M-15-producing Klebsiella pneumoniae in the intensive care unit of a French hospital. Microbial Drug Resistance (Larchmont, N.Y.), 15(1), 47-54. https://doi.org/10.1089/mdr.2009.0868
Carrër A, et al. Outbreak of CTX-M-15-producing Klebsiella Pneumoniae in the Intensive Care Unit of a French Hospital. Microb Drug Resist. 2009;15(1):47-54. PubMed PMID: 19231938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outbreak of CTX-M-15-producing Klebsiella pneumoniae in the intensive care unit of a French hospital. AU - Carrër,Amelie, AU - Lassel,Ludovic, AU - Fortineau,Nicolas, AU - Mansouri,Meriem, AU - Anguel,Nadia, AU - Richard,Christian, AU - Nordmann,Patrice, PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2010/8/25/medline SP - 47 EP - 54 JF - Microbial drug resistance (Larchmont, N.Y.) JO - Microb. Drug Resist. VL - 15 IS - 1 N2 - The CTX-M-15 extended spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were identified in 36 patients hospitalized from December 2006 to September 2007 in the medical intensive care unit (ICU) of the Bicêtre hospital, South Paris, France. The incidence of colonization and/or infection was 4.8%. Eighty-nine percent of the ESBL-producing K. pneumoniae isolates were acquired in the ICU, and only 8.3% of the patients were infected. Pulsed field gel electrophoresis (PFGE) analysis of the isolates showed that 32 isolates were clonally related and contained a 160-kb plasmid carrying the bla(CTX-M-15), bla(OXA-1), bla(TEM-1), and aac6'-Ib-cr genes. CTX-M-15-producing Escherichia coli isolates collected in the ward during the same period of time contained distinct plasmids and were not clonally related. This study highlights the possible occurrence of outbreaks due to CTX-M-producing K. pneumoniae within hospital settings, whereas CTX-Ms are mostly reported in E. coli in community-acquired infections. SN - 1931-8448 UR - https://www.unboundmedicine.com/medline/citation/19231938/Outbreak_of_CTX_M_15_producing_Klebsiella_pneumoniae_in_the_intensive_care_unit_of_a_French_hospital_ L2 - https://www.liebertpub.com/doi/full/10.1089/mdr.2009.0868?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -