Tags

Type your tag names separated by a space and hit enter

Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2).
Water Res. 2009 Apr; 43(6):1766-74.WR

Abstract

The degradation of four pharmaceutical compounds (PhACs), ibuprofen (IBU), diphenhydramine (DP), phenazone (PZ), and phenytoin (PHT) was investigated via ultraviolet (UV) photolysis and UV/H(2)O(2) process with a low-pressure (LP) UV lamp. For each PhAC tested, direct photolysis quantum yields at 254 nm were found to be ranging from 6.32 x 10(-2) to 2.79 x 10(-1)molE(-1) at pH 7. The second-order rate constants of the reaction between the PhACs and OH were determined to be from 4.86 x 10(9) to 6.67 x 10(9)M(-1)s(-1) by using a competition kinetic model which utilized para-chlorobenzoic acid (pCBA) as a reference compound. The overall effect of OH radical scavenging from humic acid (HA) and anions HCO(3)(-), NO(3)(-) was measured utilizing R(OH,UV) method through examining the aqueous photodegradation of pCBA as a probe compound. Moreover, these fundamental direct and indirect photolysis parameters were applied in the model prediction for oxidation rate constants of the PhACs in UV/H(2)O(2) process. It was found that the predicted oxidation rate constants approximated the observed ones. The results indicated that the new R(OH,UV) probe compound method was applicable for measuring background OH radical scavenging effects in water treatment process of UV/H(2)O(2). Furthermore, by GC-MS analysis, most of the intermediates created during the photodegradation of the selected PhACs in UV/H(2)O(2) process were identified. For the photodegradation of PZ, a competition mechanism existed between the direct UV photolysis and the oxidation of OH. An appropriate dosage of H(2)O(2) could hinder the occurrence of the direct photolysis.

Authors+Show Affiliations

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19232423

Citation

Yuan, Fang, et al. "Degradation of Selected Pharmaceuticals in Aqueous Solution With UV and UV/H(2)O(2)." Water Research, vol. 43, no. 6, 2009, pp. 1766-74.
Yuan F, Hu C, Hu X, et al. Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2). Water Res. 2009;43(6):1766-74.
Yuan, F., Hu, C., Hu, X., Qu, J., & Yang, M. (2009). Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2). Water Research, 43(6), 1766-74. https://doi.org/10.1016/j.watres.2009.01.008
Yuan F, et al. Degradation of Selected Pharmaceuticals in Aqueous Solution With UV and UV/H(2)O(2). Water Res. 2009;43(6):1766-74. PubMed PMID: 19232423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H(2)O(2). AU - Yuan,Fang, AU - Hu,Chun, AU - Hu,Xuexiang, AU - Qu,Jiuhui, AU - Yang,Min, Y1 - 2009/01/27/ PY - 2008/11/13/received PY - 2009/01/14/revised PY - 2009/01/14/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/7/30/medline SP - 1766 EP - 74 JF - Water research JO - Water Res VL - 43 IS - 6 N2 - The degradation of four pharmaceutical compounds (PhACs), ibuprofen (IBU), diphenhydramine (DP), phenazone (PZ), and phenytoin (PHT) was investigated via ultraviolet (UV) photolysis and UV/H(2)O(2) process with a low-pressure (LP) UV lamp. For each PhAC tested, direct photolysis quantum yields at 254 nm were found to be ranging from 6.32 x 10(-2) to 2.79 x 10(-1)molE(-1) at pH 7. The second-order rate constants of the reaction between the PhACs and OH were determined to be from 4.86 x 10(9) to 6.67 x 10(9)M(-1)s(-1) by using a competition kinetic model which utilized para-chlorobenzoic acid (pCBA) as a reference compound. The overall effect of OH radical scavenging from humic acid (HA) and anions HCO(3)(-), NO(3)(-) was measured utilizing R(OH,UV) method through examining the aqueous photodegradation of pCBA as a probe compound. Moreover, these fundamental direct and indirect photolysis parameters were applied in the model prediction for oxidation rate constants of the PhACs in UV/H(2)O(2) process. It was found that the predicted oxidation rate constants approximated the observed ones. The results indicated that the new R(OH,UV) probe compound method was applicable for measuring background OH radical scavenging effects in water treatment process of UV/H(2)O(2). Furthermore, by GC-MS analysis, most of the intermediates created during the photodegradation of the selected PhACs in UV/H(2)O(2) process were identified. For the photodegradation of PZ, a competition mechanism existed between the direct UV photolysis and the oxidation of OH. An appropriate dosage of H(2)O(2) could hinder the occurrence of the direct photolysis. SN - 0043-1354 UR - https://www.unboundmedicine.com/medline/citation/19232423/Degradation_of_selected_pharmaceuticals_in_aqueous_solution_with_UV_and_UV/H_2_O_2__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(09)00033-5 DB - PRIME DP - Unbound Medicine ER -