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Famine, death, and madness: schizophrenia in early adulthood after prenatal exposure to the Chinese Great Leap Forward Famine.

Abstract

Using data from large scale, nationally representative sample surveys, we tested the hypothesis that prenatal exposure to famine increases schizophrenia risk at adulthood by studying the Great Leap Forward Famine in China (1959-1961). Our results show that, in the urban population, being conceived and born during the famine increased the risk of developing schizophrenia at early adulthood as compared to both the pre-famine and post-famine cohorts. In the rural population, however, the post-famine cohort had the highest risk of developing schizophrenia, and there was virtually no difference in schizophrenia risk between the pre-famine and the famine cohort. This finding contrasts sharply with previous studies on the Dutch Hunger Winter as well as with smaller scale local studies in China based on hospital records. We offer an explanation for the urban-rural difference in the schizophrenia-famine relationship based on population selection by differential excess mortality and provide supportive evidence through province- and cohort-level ecological analysis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Sociology, Chinese Academy of Social Sciences, Beijing, China. sgsong@ccpr.ucla.edu

    ,

    Source

    Social science & medicine (1982) 68:7 2009 Apr pg 1315-21

    MeSH

    Adult
    China
    Cohort Studies
    Female
    History, 20th Century
    Humans
    Male
    Pregnancy
    Prenatal Exposure Delayed Effects
    Rural Population
    Schizophrenia
    Starvation
    Urban Population
    Young Adult

    Pub Type(s)

    Historical Article
    Journal Article

    Language

    eng

    PubMed ID

    19232455

    Citation

    Song, Shige, et al. "Famine, Death, and Madness: Schizophrenia in Early Adulthood After Prenatal Exposure to the Chinese Great Leap Forward Famine." Social Science & Medicine (1982), vol. 68, no. 7, 2009, pp. 1315-21.
    Song S, Wang W, Hu P. Famine, death, and madness: schizophrenia in early adulthood after prenatal exposure to the Chinese Great Leap Forward Famine. Soc Sci Med. 2009;68(7):1315-21.
    Song, S., Wang, W., & Hu, P. (2009). Famine, death, and madness: schizophrenia in early adulthood after prenatal exposure to the Chinese Great Leap Forward Famine. Social Science & Medicine (1982), 68(7), pp. 1315-21. doi:10.1016/j.socscimed.2009.01.027.
    Song S, Wang W, Hu P. Famine, Death, and Madness: Schizophrenia in Early Adulthood After Prenatal Exposure to the Chinese Great Leap Forward Famine. Soc Sci Med. 2009;68(7):1315-21. PubMed PMID: 19232455.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Famine, death, and madness: schizophrenia in early adulthood after prenatal exposure to the Chinese Great Leap Forward Famine. AU - Song,Shige, AU - Wang,Wei, AU - Hu,Peifeng, Y1 - 2009/02/14/ PY - 2008/03/26/received PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/6/6/medline SP - 1315 EP - 21 JF - Social science & medicine (1982) JO - Soc Sci Med VL - 68 IS - 7 N2 - Using data from large scale, nationally representative sample surveys, we tested the hypothesis that prenatal exposure to famine increases schizophrenia risk at adulthood by studying the Great Leap Forward Famine in China (1959-1961). Our results show that, in the urban population, being conceived and born during the famine increased the risk of developing schizophrenia at early adulthood as compared to both the pre-famine and post-famine cohorts. In the rural population, however, the post-famine cohort had the highest risk of developing schizophrenia, and there was virtually no difference in schizophrenia risk between the pre-famine and the famine cohort. This finding contrasts sharply with previous studies on the Dutch Hunger Winter as well as with smaller scale local studies in China based on hospital records. We offer an explanation for the urban-rural difference in the schizophrenia-famine relationship based on population selection by differential excess mortality and provide supportive evidence through province- and cohort-level ecological analysis. SN - 0277-9536 UR - https://www.unboundmedicine.com/medline/citation/19232455/Famine_death_and_madness:_schizophrenia_in_early_adulthood_after_prenatal_exposure_to_the_Chinese_Great_Leap_Forward_Famine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0277-9536(09)00036-7 DB - PRIME DP - Unbound Medicine ER -