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Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study.
Thromb Res. 2009 Jun; 124(2):178-84.TR

Abstract

INTRODUCTION

The present study evaluated possible relations between various markers of thrombin generation, D-dimer and venous thromboembolism in outpatients with and without the FV Leiden and the protrombin mutations.

PATIENTS AND METHODS

Our cohort consisted of 98 patients with the FV Leiden and 15 with the prothrombin mutation and an equal number of age- and gender-matched controls. All subjects were investigated due to suspicion of venous thromboembolism and the diagnosis was objectively confirmed or refuted.

RESULTS

We compared the D-dimer values and the thrombin generation markers among different patient groups (with/without thromboembolism, with/without genetic factors, gender-linked). The only statistically significant difference noted was prolonged time both for the initiation and termination of thrombin generation in patients with thrombosis. This applied to controls and to patients heterozygous for the FV Leiden. Additionally, the D-dimer values were elevated in patients with the FV Leiden. No difference was found among the patients with prothrombin mutation and their controls.

DISCUSSION

Multi-variant analysis indicated that the difference in D-dimer between FV Leiden patients and controls was due to the greater number of patients with confirmed thrombosis in the former group, a finding supported by an independent prospective study on postoperative thrombosis. Neither D-dimer concentration nor thrombin generation depend on FV Leiden. The total amount of thrombin generated was not related to diagnosis. The prolonged thrombin generation noted in controls and FV Leiden heterozygotes with thrombosis may point out different thrombin generation profiles in different patient populations and requires further studies.

Authors+Show Affiliations

Division of Internal Medicine, Department of Medicine and Care, University Hospital of Linköping, Linköping, Sweden. roza.chaireti@lio.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19232683

Citation

Chaireti, Roza, et al. "Thrombin Generation and D-dimer Concentrations in a Patient Cohort Investigated for Venous Thromboembolism. Relations to Venous Thrombosis, Factor V Leiden and Prothrombin G20210A. the LIST Study." Thrombosis Research, vol. 124, no. 2, 2009, pp. 178-84.
Chaireti R, Jennersjö C, Lindahl TL. Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study. Thromb Res. 2009;124(2):178-84.
Chaireti, R., Jennersjö, C., & Lindahl, T. L. (2009). Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study. Thrombosis Research, 124(2), 178-84. https://doi.org/10.1016/j.thromres.2008.12.033
Chaireti R, Jennersjö C, Lindahl TL. Thrombin Generation and D-dimer Concentrations in a Patient Cohort Investigated for Venous Thromboembolism. Relations to Venous Thrombosis, Factor V Leiden and Prothrombin G20210A. the LIST Study. Thromb Res. 2009;124(2):178-84. PubMed PMID: 19232683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombin generation and D-dimer concentrations in a patient cohort investigated for venous thromboembolism. Relations to venous thrombosis, factor V Leiden and prothrombin G20210A. The LIST study. AU - Chaireti,Roza, AU - Jennersjö,Cecilia, AU - Lindahl,Tomas L, Y1 - 2009/02/20/ PY - 2008/07/16/received PY - 2008/10/22/revised PY - 2008/12/09/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/9/25/medline SP - 178 EP - 84 JF - Thrombosis research JO - Thromb Res VL - 124 IS - 2 N2 - INTRODUCTION: The present study evaluated possible relations between various markers of thrombin generation, D-dimer and venous thromboembolism in outpatients with and without the FV Leiden and the protrombin mutations. PATIENTS AND METHODS: Our cohort consisted of 98 patients with the FV Leiden and 15 with the prothrombin mutation and an equal number of age- and gender-matched controls. All subjects were investigated due to suspicion of venous thromboembolism and the diagnosis was objectively confirmed or refuted. RESULTS: We compared the D-dimer values and the thrombin generation markers among different patient groups (with/without thromboembolism, with/without genetic factors, gender-linked). The only statistically significant difference noted was prolonged time both for the initiation and termination of thrombin generation in patients with thrombosis. This applied to controls and to patients heterozygous for the FV Leiden. Additionally, the D-dimer values were elevated in patients with the FV Leiden. No difference was found among the patients with prothrombin mutation and their controls. DISCUSSION: Multi-variant analysis indicated that the difference in D-dimer between FV Leiden patients and controls was due to the greater number of patients with confirmed thrombosis in the former group, a finding supported by an independent prospective study on postoperative thrombosis. Neither D-dimer concentration nor thrombin generation depend on FV Leiden. The total amount of thrombin generated was not related to diagnosis. The prolonged thrombin generation noted in controls and FV Leiden heterozygotes with thrombosis may point out different thrombin generation profiles in different patient populations and requires further studies. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/19232683/Thrombin_generation_and_D_dimer_concentrations_in_a_patient_cohort_investigated_for_venous_thromboembolism__Relations_to_venous_thrombosis_factor_V_Leiden_and_prothrombin_G20210A__The_LIST_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(09)00004-8 DB - PRIME DP - Unbound Medicine ER -