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Evaluation of dengue NS1 test kits for the diagnosis of dengue fever.
Diagn Microbiol Infect Dis. 2009 May; 64(1):31-6.DM

Abstract

Detection of the dengue NS1 antigen during the symptomatic phase of illness represents an important advance in the diagnosis of dengue fever. The sensitivity of 2 commercial kits was evaluated in a panel of 91 serum samples collected at defined intervals after onset of symptomatic dengue fever. The sensitivity of the Bio-Rad Platelia (Bio-Rad Laboratories, Marnes-La-Coquette, France) dengue NS1 assay was 73.6% (95% confidence interval [CI], 63.7-81.6). The Panbio Early ELISA (Panbio Diagnostics, Brisbane, Australia) had a sensitivity of 63.7% (95% CI, 53.5-72.9). Four samples were equivocal in the Panbio assay. The sensitivity of both assays was highest on the 2nd to 4th day after illness onset and in primary dengue infections. Both assays will be useful for the detection of dengue viral infections early in the course of the infection, especially in nonendemic countries.

Authors+Show Affiliations

School of Medicine, James Cook University, Cairns Base Hospital, PO Box 902, Cairns, Queensland 4870, Australia. john.mcbride@jcu.edu.au

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

19232865

Citation

McBride, William John Hannan. "Evaluation of Dengue NS1 Test Kits for the Diagnosis of Dengue Fever." Diagnostic Microbiology and Infectious Disease, vol. 64, no. 1, 2009, pp. 31-6.
McBride WJ. Evaluation of dengue NS1 test kits for the diagnosis of dengue fever. Diagn Microbiol Infect Dis. 2009;64(1):31-6.
McBride, W. J. (2009). Evaluation of dengue NS1 test kits for the diagnosis of dengue fever. Diagnostic Microbiology and Infectious Disease, 64(1), 31-6. https://doi.org/10.1016/j.diagmicrobio.2009.01.002
McBride WJ. Evaluation of Dengue NS1 Test Kits for the Diagnosis of Dengue Fever. Diagn Microbiol Infect Dis. 2009;64(1):31-6. PubMed PMID: 19232865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of dengue NS1 test kits for the diagnosis of dengue fever. A1 - McBride,William John Hannan, Y1 - 2009/02/18/ PY - 2008/10/06/received PY - 2008/12/27/revised PY - 2009/01/07/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/5/23/medline SP - 31 EP - 6 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 64 IS - 1 N2 - Detection of the dengue NS1 antigen during the symptomatic phase of illness represents an important advance in the diagnosis of dengue fever. The sensitivity of 2 commercial kits was evaluated in a panel of 91 serum samples collected at defined intervals after onset of symptomatic dengue fever. The sensitivity of the Bio-Rad Platelia (Bio-Rad Laboratories, Marnes-La-Coquette, France) dengue NS1 assay was 73.6% (95% confidence interval [CI], 63.7-81.6). The Panbio Early ELISA (Panbio Diagnostics, Brisbane, Australia) had a sensitivity of 63.7% (95% CI, 53.5-72.9). Four samples were equivocal in the Panbio assay. The sensitivity of both assays was highest on the 2nd to 4th day after illness onset and in primary dengue infections. Both assays will be useful for the detection of dengue viral infections early in the course of the infection, especially in nonendemic countries. SN - 1879-0070 UR - https://www.unboundmedicine.com/medline/citation/19232865/Evaluation_of_dengue_NS1_test_kits_for_the_diagnosis_of_dengue_fever_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(09)00007-8 DB - PRIME DP - Unbound Medicine ER -