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Expression of VEGF-receptor system in conceptus during peri-implantation period and endometrial and luteal expression of soluble VEGFR-1 in the pig.
Theriogenology. 2009 May; 71(8):1298-306.T

Abstract

In view of the importance of vascular events observed during gestation, it was hypothesized that the VEGF-receptor system plays a critical role during early pregnancy and maternal recognition of pregnancy in pigs. This hypothesis was tested by examining the expression of the VEGF-receptor system in the porcine conceptus. Additionally, the endometrium, corpus luteum (CL) and embryos were studied for the expression of soluble VEGF receptor 1 (sVEGFR-1), the strong endogenous antagonist of VEGF. The expression patterns show that VEGF164 mRNA levels increase gradually in line with conceptus development, whereas VEGF120 and VEGFR-2 remain unchanged during the peri-implantation period. Interestingly, elevated VEGFR-1 expression was observed in conceptuses on days 15-16 of gestation (P<0.05). Comparison of the endometrial sVEGFR-1 mRNA expression revealed up-regulation on days 12 and 15-16 of pregnancy (P<0.01 and P<0.05, respectively). Furthermore, increased sVEGFR-1 levels were observed on day 12 of the estrous cycle in the CL (P<0.05). Concluding, it seems that conceptus-derived VEGF164 plays crucial role in peri-implantation vascular events in pigs. These results support a potential role of VEGFR-1 in the proper growth and development of porcine conceptus during pregnancy. Moreover, expression patterns of sVEGFR-1 in the endometrium of pregnant pigs suggest that it may participate in vascular remodeling important for successful implantation. Finally, luteal sVEGFR-1 may be involved in the maintenance of CL function whenever pregnancy occurs in pigs.

Authors+Show Affiliations

Institute of Animal Reproduction and Food Research Polish Academy of Sciences (IARFR PAS), Tuwima 10, 10-747 Olsztyn, Poland. moka@pan.olsztyn.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19233458

Citation

Kaczmarek, M M., et al. "Expression of VEGF-receptor System in Conceptus During Peri-implantation Period and Endometrial and Luteal Expression of Soluble VEGFR-1 in the Pig." Theriogenology, vol. 71, no. 8, 2009, pp. 1298-306.
Kaczmarek MM, Kiewisz J, Schams D, et al. Expression of VEGF-receptor system in conceptus during peri-implantation period and endometrial and luteal expression of soluble VEGFR-1 in the pig. Theriogenology. 2009;71(8):1298-306.
Kaczmarek, M. M., Kiewisz, J., Schams, D., & Ziecik, A. J. (2009). Expression of VEGF-receptor system in conceptus during peri-implantation period and endometrial and luteal expression of soluble VEGFR-1 in the pig. Theriogenology, 71(8), 1298-306. https://doi.org/10.1016/j.theriogenology.2008.12.022
Kaczmarek MM, et al. Expression of VEGF-receptor System in Conceptus During Peri-implantation Period and Endometrial and Luteal Expression of Soluble VEGFR-1 in the Pig. Theriogenology. 2009;71(8):1298-306. PubMed PMID: 19233458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of VEGF-receptor system in conceptus during peri-implantation period and endometrial and luteal expression of soluble VEGFR-1 in the pig. AU - Kaczmarek,M M, AU - Kiewisz,J, AU - Schams,D, AU - Ziecik,A J, Y1 - 2009/02/23/ PY - 2008/10/14/received PY - 2008/12/22/revised PY - 2008/12/29/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/7/2/medline SP - 1298 EP - 306 JF - Theriogenology JO - Theriogenology VL - 71 IS - 8 N2 - In view of the importance of vascular events observed during gestation, it was hypothesized that the VEGF-receptor system plays a critical role during early pregnancy and maternal recognition of pregnancy in pigs. This hypothesis was tested by examining the expression of the VEGF-receptor system in the porcine conceptus. Additionally, the endometrium, corpus luteum (CL) and embryos were studied for the expression of soluble VEGF receptor 1 (sVEGFR-1), the strong endogenous antagonist of VEGF. The expression patterns show that VEGF164 mRNA levels increase gradually in line with conceptus development, whereas VEGF120 and VEGFR-2 remain unchanged during the peri-implantation period. Interestingly, elevated VEGFR-1 expression was observed in conceptuses on days 15-16 of gestation (P<0.05). Comparison of the endometrial sVEGFR-1 mRNA expression revealed up-regulation on days 12 and 15-16 of pregnancy (P<0.01 and P<0.05, respectively). Furthermore, increased sVEGFR-1 levels were observed on day 12 of the estrous cycle in the CL (P<0.05). Concluding, it seems that conceptus-derived VEGF164 plays crucial role in peri-implantation vascular events in pigs. These results support a potential role of VEGFR-1 in the proper growth and development of porcine conceptus during pregnancy. Moreover, expression patterns of sVEGFR-1 in the endometrium of pregnant pigs suggest that it may participate in vascular remodeling important for successful implantation. Finally, luteal sVEGFR-1 may be involved in the maintenance of CL function whenever pregnancy occurs in pigs. SN - 0093-691X UR - https://www.unboundmedicine.com/medline/citation/19233458/Expression_of_VEGF_receptor_system_in_conceptus_during_peri_implantation_period_and_endometrial_and_luteal_expression_of_soluble_VEGFR_1_in_the_pig_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0093-691X(09)00022-3 DB - PRIME DP - Unbound Medicine ER -