Tags

Type your tag names separated by a space and hit enter

The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats.
Clin Nutr 2009; 28(3):338-45CN

Abstract

BACKGROUND & AIMS

The aim of this study was to investigate the effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on the liver fibrosis induced by chronic carbon tetrachloride (CCl(4)) administration in rats.

METHODS

Rats were divided randomly into four groups: control, CCl(4), and two FSSC groups. Except for rats in the control group, all rats were orally administered CCl(4) twice a week for 8 weeks. Rats in the FSSC groups were treated daily with FSSC (0.5 or 1.5 g/kg) through gastrogavage for the entire experimental period.

RESULTS

CCl(4) caused liver damage, as characterized by increases in levels of plasma transaminase, hepatic malondialdehyde, and hydroxyproline, in addition to increases in spleen and liver weights and decreases in plasma albumin levels. Compared with CCl(4) group, FSSC (1.5 g/kg) treatment significantly decreased the spleen (P<0.01) and liver (P<0.01) weights, the activities of transaminase (P<0.05), and levels of hepatic malondialdehyde (P<0.05) and hydroxyproline (P<0.01); however, the treatment increased plasma albumin level (P<0.05). The pathological results also showed that FSSC (1.5 g/kg) suppressed hepatic inflammation, steatosis and necrosis. Data for hepatic fibrosis were expressed as the mean percentage of the total hepatic area in the tissue sections. FSSC (1.5 g/kg) treatment significantly decreased the hepatic fibrosis (12.8+/-1.2 and 6.4+/-0.7 in CCl(4) and FSSC group, respectively, P<0.001). RT-PCR analysis showed that FSSC (1.5 g/kg) treatment decreased the expression of methionine adenosyltransferase 2A (P<0.01), collagen (alpha1)(I) (3.15+/-0.05 and 1.52+/-0.04 in CCl(4) and FSSC groups, respectively, P<0.001), and transforming growth factor-beta1 (2.50+/-0.05 and 1.21+/-0.04 in CCl(4) and FSSC groups, respectively, P<0.001), apart from increasing the expression of methionine adenosyltransferase 1A (P<0.05).

CONCLUSION

These results showed that FSSC protects the liver against CCl(4) damage in rats.

Authors+Show Affiliations

Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19233522

Citation

Lai, Jinn-Tsyy, et al. "The Protective Effects of a Fermented Substance From Saccharomyces Cerevisiae On Carbon Tetrachloride-induced Liver Damage in Rats." Clinical Nutrition (Edinburgh, Scotland), vol. 28, no. 3, 2009, pp. 338-45.
Lai JT, Hsieh WT, Fang HL, et al. The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats. Clin Nutr. 2009;28(3):338-45.
Lai, J. T., Hsieh, W. T., Fang, H. L., & Lin, W. C. (2009). The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats. Clinical Nutrition (Edinburgh, Scotland), 28(3), pp. 338-45. doi:10.1016/j.clnu.2009.01.011.
Lai JT, et al. The Protective Effects of a Fermented Substance From Saccharomyces Cerevisiae On Carbon Tetrachloride-induced Liver Damage in Rats. Clin Nutr. 2009;28(3):338-45. PubMed PMID: 19233522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats. AU - Lai,Jinn-Tsyy, AU - Hsieh,Wen-Tsong, AU - Fang,Hsun-Lang, AU - Lin,Wen-Chuan, Y1 - 2009/02/23/ PY - 2008/10/01/received PY - 2009/01/08/revised PY - 2009/01/16/accepted PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/8/14/medline SP - 338 EP - 45 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 28 IS - 3 N2 - BACKGROUND & AIMS: The aim of this study was to investigate the effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on the liver fibrosis induced by chronic carbon tetrachloride (CCl(4)) administration in rats. METHODS: Rats were divided randomly into four groups: control, CCl(4), and two FSSC groups. Except for rats in the control group, all rats were orally administered CCl(4) twice a week for 8 weeks. Rats in the FSSC groups were treated daily with FSSC (0.5 or 1.5 g/kg) through gastrogavage for the entire experimental period. RESULTS: CCl(4) caused liver damage, as characterized by increases in levels of plasma transaminase, hepatic malondialdehyde, and hydroxyproline, in addition to increases in spleen and liver weights and decreases in plasma albumin levels. Compared with CCl(4) group, FSSC (1.5 g/kg) treatment significantly decreased the spleen (P<0.01) and liver (P<0.01) weights, the activities of transaminase (P<0.05), and levels of hepatic malondialdehyde (P<0.05) and hydroxyproline (P<0.01); however, the treatment increased plasma albumin level (P<0.05). The pathological results also showed that FSSC (1.5 g/kg) suppressed hepatic inflammation, steatosis and necrosis. Data for hepatic fibrosis were expressed as the mean percentage of the total hepatic area in the tissue sections. FSSC (1.5 g/kg) treatment significantly decreased the hepatic fibrosis (12.8+/-1.2 and 6.4+/-0.7 in CCl(4) and FSSC group, respectively, P<0.001). RT-PCR analysis showed that FSSC (1.5 g/kg) treatment decreased the expression of methionine adenosyltransferase 2A (P<0.01), collagen (alpha1)(I) (3.15+/-0.05 and 1.52+/-0.04 in CCl(4) and FSSC groups, respectively, P<0.001), and transforming growth factor-beta1 (2.50+/-0.05 and 1.21+/-0.04 in CCl(4) and FSSC groups, respectively, P<0.001), apart from increasing the expression of methionine adenosyltransferase 1A (P<0.05). CONCLUSION: These results showed that FSSC protects the liver against CCl(4) damage in rats. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/19233522/The_protective_effects_of_a_fermented_substance_from_Saccharomyces_cerevisiae_on_carbon_tetrachloride_induced_liver_damage_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(09)00022-3 DB - PRIME DP - Unbound Medicine ER -