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Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model.
Immunopharmacol Immunotoxicol. 2009; 31(1):94-102.II

Abstract

In this study, we evaluated the anti-oxidant and anti-inflammatory activities of the medicinal plant, Vernonia cinerea L (Asteraceae) using in vitro as well as in vivo models. Methanolic extract of Vernonia cinerea was found to scavenge the hydroxyl radical generated by Fenton reaction (IC(50)130 microg/ml), Superoxide generated by photo reduction of riboflavin (IC(50)190 microg/ml) and inhibited lipid peroxidation significantly (IC(50)130.5 microg/ml). The drug also scavenged nitric oxide (IC(50)210 microg/ml). Intraperitoneal administration of Vernonia cinerea was found to inhibit the PMA induced Superoxide generation in mice peritoneal macrophages. The administration of Vernonia cinerea to mice significantly increased the levels of catalase, superoxide dismutase, glutathione, glutathione peroxidase and glutathione-S transferase in blood and liver, whereas lipid peroxidation activity was significantly decreased. It was also found that Vernonia cinerea extract significantly inhibited carrageenan induced inflammation, compared with control models. Down regulation of pro-inflammatory cytokine level and gene expression were also support the above result.

Authors+Show Affiliations

Amala Cancer Research Centre, Amala Nagar, Kerala State, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19234957

Citation

Kumar, P Pratheesh, and Girija Kuttan. "Vernonia Cinerea L. Scavenges Free Radicals and Regulates Nitric Oxide and Proinflammatory Cytokines Profile in Carrageenan Induced Paw Edema Model." Immunopharmacology and Immunotoxicology, vol. 31, no. 1, 2009, pp. 94-102.
Kumar PP, Kuttan G. Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. Immunopharmacol Immunotoxicol. 2009;31(1):94-102.
Kumar, P. P., & Kuttan, G. (2009). Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. Immunopharmacology and Immunotoxicology, 31(1), 94-102. https://doi.org/10.1080/08923970802438391
Kumar PP, Kuttan G. Vernonia Cinerea L. Scavenges Free Radicals and Regulates Nitric Oxide and Proinflammatory Cytokines Profile in Carrageenan Induced Paw Edema Model. Immunopharmacol Immunotoxicol. 2009;31(1):94-102. PubMed PMID: 19234957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. AU - Kumar,P Pratheesh, AU - Kuttan,Girija, PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/5/12/medline SP - 94 EP - 102 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 31 IS - 1 N2 - In this study, we evaluated the anti-oxidant and anti-inflammatory activities of the medicinal plant, Vernonia cinerea L (Asteraceae) using in vitro as well as in vivo models. Methanolic extract of Vernonia cinerea was found to scavenge the hydroxyl radical generated by Fenton reaction (IC(50)130 microg/ml), Superoxide generated by photo reduction of riboflavin (IC(50)190 microg/ml) and inhibited lipid peroxidation significantly (IC(50)130.5 microg/ml). The drug also scavenged nitric oxide (IC(50)210 microg/ml). Intraperitoneal administration of Vernonia cinerea was found to inhibit the PMA induced Superoxide generation in mice peritoneal macrophages. The administration of Vernonia cinerea to mice significantly increased the levels of catalase, superoxide dismutase, glutathione, glutathione peroxidase and glutathione-S transferase in blood and liver, whereas lipid peroxidation activity was significantly decreased. It was also found that Vernonia cinerea extract significantly inhibited carrageenan induced inflammation, compared with control models. Down regulation of pro-inflammatory cytokine level and gene expression were also support the above result. SN - 1532-2513 UR - https://www.unboundmedicine.com/medline/citation/19234957/Vernonia_cinerea_L__scavenges_free_radicals_and_regulates_nitric_oxide_and_proinflammatory_cytokines_profile_in_carrageenan_induced_paw_edema_model_ L2 - https://www.tandfonline.com/doi/full/10.1080/08923970802438391 DB - PRIME DP - Unbound Medicine ER -