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Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5.
Nat Prod Res. 2009; 23(3):212-8.NP

Abstract

The cultivation of terrestrial Streptomyces Sp. Eg5 delivered two new aromatic polyketides, 2-butyryl-1,8-dihydroxy-3-methylanthraquinone (2), or mansoquinone, and 2-acetyl-1,8-dihydroxy-3-methyl-anthra-quinone (3) along with the known 2-ethyl-1,8-dihydroxy-3-methylanthraquinone (1). The structure of mansoquinone (2) was elucidated using detailed spectral ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC and HRMS) analysis. This is the first report of the isolation of 3 from natural source. Mansoquinone (2) exhibited moderate antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.

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Publisher Full Text

Authors+Show Affiliations

Abdelfattah MS
Faculty of Science, Chemistry Department, Helwan University, Ain Helwan, Cairo, Egypt. mabdelfattah_13@yahoo.com

MeSH

AnthraquinonesAnti-Bacterial AgentsBacillus subtilisChromatography, High Pressure LiquidEscherichia coliMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStreptomyces

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19235021

Citation

Abdelfattah, Mohamed S.. "Mansoquinone: Isolation and Structure Elucidation of New Antibacterial Aromatic Polyketides From Terrestrial Streptomyces Sp. Eg5." Natural Product Research, vol. 23, no. 3, 2009, pp. 212-8.
Abdelfattah MS. Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5. Nat Prod Res. 2009;23(3):212-8.
Abdelfattah, M. S. (2009). Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5. Natural Product Research, 23(3), 212-8. https://doi.org/10.1080/14786410801961550
Abdelfattah MS. Mansoquinone: Isolation and Structure Elucidation of New Antibacterial Aromatic Polyketides From Terrestrial Streptomyces Sp. Eg5. Nat Prod Res. 2009;23(3):212-8. PubMed PMID: 19235021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5. A1 - Abdelfattah,Mohamed S, PY - 2009/2/24/entrez PY - 2009/2/24/pubmed PY - 2009/4/7/medline SP - 212 EP - 8 JF - Natural product research JO - Nat Prod Res VL - 23 IS - 3 N2 - The cultivation of terrestrial Streptomyces Sp. Eg5 delivered two new aromatic polyketides, 2-butyryl-1,8-dihydroxy-3-methylanthraquinone (2), or mansoquinone, and 2-acetyl-1,8-dihydroxy-3-methyl-anthra-quinone (3) along with the known 2-ethyl-1,8-dihydroxy-3-methylanthraquinone (1). The structure of mansoquinone (2) was elucidated using detailed spectral ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC and HRMS) analysis. This is the first report of the isolation of 3 from natural source. Mansoquinone (2) exhibited moderate antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/19235021/Mansoquinone:_isolation_and_structure_elucidation_of_new_antibacterial_aromatic_polyketides_from_terrestrial_Streptomyces_Sp__Eg5_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410801961550 DB - PRIME DP - Unbound Medicine ER -