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Preoperative levels of plasma micronutrients are related to endometrial cancer risk.

Abstract

OBJECTIVE

To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women.

DESIGN

Hospital-based case-control study.

SETTING

Seven tertiary medical institutes in Korea.

POPULATION

Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period.

METHODS

Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.

MAIN OUTCOME MEASURES

Effect of micronutrients on endometrial cancer risk.

RESULTS

The mean concentration of plasma beta-carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and gamma-tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of beta-carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma beta-carotene and lycopene had a 0.12-fold (95% confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95% CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), alpha-tocopherol (p for trend=0.322), and gamma-tocopherol (p for trend=0.087) showed no association with endometrial cancer risk.

CONCLUSIONS

Plasma levels of beta-carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Kyung Hee University College of Medicine, Seoul, Korea.

    , , , , , , , , , ,

    Source

    MeSH

    Analysis of Variance
    Anticarcinogenic Agents
    Antioxidants
    Body Mass Index
    Carotenoids
    Case-Control Studies
    Chromatography, High Pressure Liquid
    Contraceptives, Oral
    Dietary Supplements
    Educational Status
    Endometrial Neoplasms
    Female
    Humans
    Logistic Models
    Lycopene
    Micronutrients
    Middle Aged
    Risk Factors
    Smoking
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19235557

    Citation

    Jeong, Nan-Hee, et al. "Preoperative Levels of Plasma Micronutrients Are Related to Endometrial Cancer Risk." Acta Obstetricia Et Gynecologica Scandinavica, vol. 88, no. 4, 2009, pp. 434-9.
    Jeong NH, Song ES, Lee JM, et al. Preoperative levels of plasma micronutrients are related to endometrial cancer risk. Acta Obstet Gynecol Scand. 2009;88(4):434-9.
    Jeong, N. H., Song, E. S., Lee, J. M., Lee, K. B., Kim, M. K., Yun, Y. M., ... Kwon, Y. I. (2009). Preoperative levels of plasma micronutrients are related to endometrial cancer risk. Acta Obstetricia Et Gynecologica Scandinavica, 88(4), pp. 434-9. doi:10.1080/00016340902767187.
    Jeong NH, et al. Preoperative Levels of Plasma Micronutrients Are Related to Endometrial Cancer Risk. Acta Obstet Gynecol Scand. 2009;88(4):434-9. PubMed PMID: 19235557.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Preoperative levels of plasma micronutrients are related to endometrial cancer risk. AU - Jeong,Nan-Hee, AU - Song,Eun-Seop, AU - Lee,Jong-Min, AU - Lee,Kwang-Beom, AU - Kim,Mi-Kyung, AU - Yun,Young-Mi, AU - Lee,Jae-Kwan, AU - Son,Sung-Kyong, AU - Lee,Jung-Pil, AU - Kim,Jae-Hoon, AU - Hur,Soo-Young, AU - Kwon,Yong-Il, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/4/22/medline SP - 434 EP - 9 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 88 IS - 4 N2 - OBJECTIVE: To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. DESIGN: Hospital-based case-control study. SETTING: Seven tertiary medical institutes in Korea. POPULATION: Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period. METHODS: Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. MAIN OUTCOME MEASURES: Effect of micronutrients on endometrial cancer risk. RESULTS: The mean concentration of plasma beta-carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and gamma-tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of beta-carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma beta-carotene and lycopene had a 0.12-fold (95% confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95% CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), alpha-tocopherol (p for trend=0.322), and gamma-tocopherol (p for trend=0.087) showed no association with endometrial cancer risk. CONCLUSIONS: Plasma levels of beta-carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/19235557/Preoperative_levels_of_plasma_micronutrients_are_related_to_endometrial_cancer_risk_ L2 - https://doi.org/10.1080/00016340902767187 DB - PRIME DP - Unbound Medicine ER -