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Drug dissolution rate measurements--evaluation of the rotating disc method.
Pharm Dev Technol. 2009; 14(4):400-8.PD

Abstract

Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model substances. Existing theory for the rotating disc was compared with experiments and a computational fluid dynamics (CFD) model simulating the USP vessel. Simulations showed that it is possible to predict mass transfer controlled drug release rates within the laminar flow regime. Mass transfer coefficients obtained from the CFD model were in better agreement with experimental data than those obtained from existing theory. It was concluded that the hydrodynamic boundary layer controlling release rates was in reality thicker than existing theory would suggest.

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Authors+Show Affiliations

Kaunisto E
Department of Chemical Engineering, Lund University, Lund, Sweden. Erik.Kaunisto@chemeng.lth.se
Nilsson B
No affiliation info available
Axelsson A
No affiliation info available

MeSH

AspirinBenzoic AcidChemistry, PharmaceuticalModels, TheoreticalSolubilityTechnology, Pharmaceutical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19235631

Citation

Kaunisto, Erik, et al. "Drug Dissolution Rate Measurements--evaluation of the Rotating Disc Method." Pharmaceutical Development and Technology, vol. 14, no. 4, 2009, pp. 400-8.
Kaunisto E, Nilsson B, Axelsson A. Drug dissolution rate measurements--evaluation of the rotating disc method. Pharm Dev Technol. 2009;14(4):400-8.
Kaunisto, E., Nilsson, B., & Axelsson, A. (2009). Drug dissolution rate measurements--evaluation of the rotating disc method. Pharmaceutical Development and Technology, 14(4), 400-8. https://doi.org/10.1080/10837450802712641
Kaunisto E, Nilsson B, Axelsson A. Drug Dissolution Rate Measurements--evaluation of the Rotating Disc Method. Pharm Dev Technol. 2009;14(4):400-8. PubMed PMID: 19235631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug dissolution rate measurements--evaluation of the rotating disc method. AU - Kaunisto,Erik, AU - Nilsson,Bernt, AU - Axelsson,Anders, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/12/23/medline SP - 400 EP - 8 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 14 IS - 4 N2 - Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model substances. Existing theory for the rotating disc was compared with experiments and a computational fluid dynamics (CFD) model simulating the USP vessel. Simulations showed that it is possible to predict mass transfer controlled drug release rates within the laminar flow regime. Mass transfer coefficients obtained from the CFD model were in better agreement with experimental data than those obtained from existing theory. It was concluded that the hydrodynamic boundary layer controlling release rates was in reality thicker than existing theory would suggest. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/19235631/Drug_dissolution_rate_measurements__evaluation_of_the_rotating_disc_method_ L2 - https://www.tandfonline.com/doi/full/10.1080/10837450802712641 DB - PRIME DP - Unbound Medicine ER -