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Severity of liver disease predicts the development of glucose abnormalities in patients with chronic hepatitis B or C following achievement of sustained virological response to antiviral therapy.
J Med Virol. 2009 Apr; 81(4):610-8.JM

Abstract

A higher prevalence of glucose abnormalities has been reported in patients with hepatitis C virus (HCV) infection compared to patients with hepatitis B virus (HBV) infection. However, previous studies considered some confounding factors and ignored others, which might influence the comparative risk assessment between HBV and HCV infections. Fasting plasma glucose concentration, severity of liver disease and viral load were determined in 220 patients with HCV genotype 4 infection, and 200 patients with HBV infection. Patients completing antiviral therapy were followed-up, and the fasting plasma glucose levels were determined in patients with and without sustained virological response. The prevalence of glucose abnormalities in HCV infection (41%) was significantly higher than that in HBV infection (16%). However, when controlling the severity of liver disease and other risk factors, the prevalence of glucose abnormalities in patients with HCV infection was comparable to that in patients with HBV infection. After attaining of sustained virological response, a decrease of the median fasting plasma glucose value was observed only in chronic hepatitis C. In the group of patients with normal fasting plasma glucose levels, an association of nonsustained virological response with the development of impaired fasting glucose was only observed in chronic hepatitis C. The severity of liver disease was a common predictor of impaired fasting glucose in hepatitis B and C infections. These results indicate that high prevalence of glucose abnormalities can be associated with HBV- and HCV-related liver disease, and that clearance of HCV, but not HBV, may improve glucose metabolism.

Authors+Show Affiliations

Faculty of Medicine, Department of Microbiology, Kuwait University, Safat, Kuwait. wchehadeh@hsc.edu.kwNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19235842

Citation

Chehadeh, Wassim, and Widad Al-Nakib. "Severity of Liver Disease Predicts the Development of Glucose Abnormalities in Patients With Chronic Hepatitis B or C Following Achievement of Sustained Virological Response to Antiviral Therapy." Journal of Medical Virology, vol. 81, no. 4, 2009, pp. 610-8.
Chehadeh W, Al-Nakib W. Severity of liver disease predicts the development of glucose abnormalities in patients with chronic hepatitis B or C following achievement of sustained virological response to antiviral therapy. J Med Virol. 2009;81(4):610-8.
Chehadeh, W., & Al-Nakib, W. (2009). Severity of liver disease predicts the development of glucose abnormalities in patients with chronic hepatitis B or C following achievement of sustained virological response to antiviral therapy. Journal of Medical Virology, 81(4), 610-8. https://doi.org/10.1002/jmv.21396
Chehadeh W, Al-Nakib W. Severity of Liver Disease Predicts the Development of Glucose Abnormalities in Patients With Chronic Hepatitis B or C Following Achievement of Sustained Virological Response to Antiviral Therapy. J Med Virol. 2009;81(4):610-8. PubMed PMID: 19235842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severity of liver disease predicts the development of glucose abnormalities in patients with chronic hepatitis B or C following achievement of sustained virological response to antiviral therapy. AU - Chehadeh,Wassim, AU - Al-Nakib,Widad, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/3/26/medline SP - 610 EP - 8 JF - Journal of medical virology JO - J Med Virol VL - 81 IS - 4 N2 - A higher prevalence of glucose abnormalities has been reported in patients with hepatitis C virus (HCV) infection compared to patients with hepatitis B virus (HBV) infection. However, previous studies considered some confounding factors and ignored others, which might influence the comparative risk assessment between HBV and HCV infections. Fasting plasma glucose concentration, severity of liver disease and viral load were determined in 220 patients with HCV genotype 4 infection, and 200 patients with HBV infection. Patients completing antiviral therapy were followed-up, and the fasting plasma glucose levels were determined in patients with and without sustained virological response. The prevalence of glucose abnormalities in HCV infection (41%) was significantly higher than that in HBV infection (16%). However, when controlling the severity of liver disease and other risk factors, the prevalence of glucose abnormalities in patients with HCV infection was comparable to that in patients with HBV infection. After attaining of sustained virological response, a decrease of the median fasting plasma glucose value was observed only in chronic hepatitis C. In the group of patients with normal fasting plasma glucose levels, an association of nonsustained virological response with the development of impaired fasting glucose was only observed in chronic hepatitis C. The severity of liver disease was a common predictor of impaired fasting glucose in hepatitis B and C infections. These results indicate that high prevalence of glucose abnormalities can be associated with HBV- and HCV-related liver disease, and that clearance of HCV, but not HBV, may improve glucose metabolism. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/19235842/Severity_of_liver_disease_predicts_the_development_of_glucose_abnormalities_in_patients_with_chronic_hepatitis_B_or_C_following_achievement_of_sustained_virological_response_to_antiviral_therapy_ L2 - https://doi.org/10.1002/jmv.21396 DB - PRIME DP - Unbound Medicine ER -