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Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study.
J Dig Dis 2009; 10(1):61-70JD

Abstract

AIM

Some probiotics improve digestive comfort of people with Irritable Bowel Syndrome, but this needs confirmation in a healthy population. The objective of this pilot study was to investigate the effect of consuming fermented milk containing the probiotics Bifidobacterium lactis DN-173010 and yoghourt strains (test product) on digestive comfort and symptoms amongst adults without diagnosed gastrointestinal disorders.

METHODS

The study was designed to approximate a real-life situation, by using a branded product in the intervention groups. In an open-label, randomized, controlled trial, 371 adults reporting digestive discomfort were randomized into three groups who had a daily consumption of either one or two pots of test product over 2 weeks, or to follow their usual diet. Digestive comfort and bother from digestive symptoms were assessed by questionnaire at baseline and follow-up (per protocol population n = 360). Self-reported change in digestive comfort and computed change between baseline and follow-up for each of 20 items were compared between groups (Cochran-Mantel-Haenszel test).

RESULTS

A higher percentage of participants consuming the test product reported improved digestive comfort (1-pot group 82.5%; 2-pot group 84.3%), than controls (2.9%). Their self-reported change scores differed significantly (P < 0.001). For both test product groups, almost all symptom scores improved significantly more than controls (P < 0.001). There were no significant differences between 1-pot and 2-pot groups.

CONCLUSIONS

This pilot study shows that daily consumption of a probiotic food in real-life conditions may be useful in improving digestive comfort and symptom experience of adults from general population. Further double-blind randomized controlled studies are required to confirm these health benefits.

Authors+Show Affiliations

Danone Research, Palaiseau Cedex, France. denis.guyonnet@danone.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19236549

Citation

Guyonnet, Denis, et al. "Fermented Milk Containing Bifidobacterium Lactis DN-173 010 Improved Self-reported Digestive Comfort Amongst a General Population of Adults. a Randomized, Open-label, Controlled, Pilot Study." Journal of Digestive Diseases, vol. 10, no. 1, 2009, pp. 61-70.
Guyonnet D, Woodcock A, Stefani B, et al. Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study. J Dig Dis. 2009;10(1):61-70.
Guyonnet, D., Woodcock, A., Stefani, B., Trevisan, C., & Hall, C. (2009). Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study. Journal of Digestive Diseases, 10(1), pp. 61-70. doi:10.1111/j.1751-2980.2008.00366.x.
Guyonnet D, et al. Fermented Milk Containing Bifidobacterium Lactis DN-173 010 Improved Self-reported Digestive Comfort Amongst a General Population of Adults. a Randomized, Open-label, Controlled, Pilot Study. J Dig Dis. 2009;10(1):61-70. PubMed PMID: 19236549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot study. AU - Guyonnet,Denis, AU - Woodcock,Alison, AU - Stefani,Blandine, AU - Trevisan,Cristina, AU - Hall,Claire, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/7/9/medline SP - 61 EP - 70 JF - Journal of digestive diseases JO - J Dig Dis VL - 10 IS - 1 N2 - AIM: Some probiotics improve digestive comfort of people with Irritable Bowel Syndrome, but this needs confirmation in a healthy population. The objective of this pilot study was to investigate the effect of consuming fermented milk containing the probiotics Bifidobacterium lactis DN-173010 and yoghourt strains (test product) on digestive comfort and symptoms amongst adults without diagnosed gastrointestinal disorders. METHODS: The study was designed to approximate a real-life situation, by using a branded product in the intervention groups. In an open-label, randomized, controlled trial, 371 adults reporting digestive discomfort were randomized into three groups who had a daily consumption of either one or two pots of test product over 2 weeks, or to follow their usual diet. Digestive comfort and bother from digestive symptoms were assessed by questionnaire at baseline and follow-up (per protocol population n = 360). Self-reported change in digestive comfort and computed change between baseline and follow-up for each of 20 items were compared between groups (Cochran-Mantel-Haenszel test). RESULTS: A higher percentage of participants consuming the test product reported improved digestive comfort (1-pot group 82.5%; 2-pot group 84.3%), than controls (2.9%). Their self-reported change scores differed significantly (P < 0.001). For both test product groups, almost all symptom scores improved significantly more than controls (P < 0.001). There were no significant differences between 1-pot and 2-pot groups. CONCLUSIONS: This pilot study shows that daily consumption of a probiotic food in real-life conditions may be useful in improving digestive comfort and symptom experience of adults from general population. Further double-blind randomized controlled studies are required to confirm these health benefits. SN - 1751-2980 UR - https://www.unboundmedicine.com/medline/citation/19236549/Fermented_milk_containing_Bifidobacterium_lactis_DN_173_010_improved_self_reported_digestive_comfort_amongst_a_general_population_of_adults__A_randomized_open_label_controlled_pilot_study_ L2 - https://doi.org/10.1111/j.1751-2980.2008.00366.x DB - PRIME DP - Unbound Medicine ER -