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Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure.
Crit Care Med. 2009 Mar; 37(3):1121-4.CC

Abstract

OBJECTIVES

Extracorporeal membrane oxygenation (ECMO) is known to improve cardiorespiratory function and outcome in neonates with severe respiratory failure. In this study, we tested two hypotheses: 1) neonates with severe respiratory failure exhibit alterations of the microcirculation and 2) after ECMO therapy these microcirculatory alterations are improved.

DESIGN

Single-center prospective observational study.

SETTING

Intensive care unit of a level III university children's hospital.

PATIENTS

Term neonates receiving venoarterial ECMO. Control patients with and without respiratory failure.

MEASUREMENTS AND MAIN RESULTS

The microcirculation was assessed in the buccal mucosa, using orthogonal polarization spectral imaging, before and after ECMO. Functional capillary density was lower in patients with severe respiratory failure before ECMO (n = 14) compared with control patients (n = 10; p < 0.01). Functional capillary density had increased significantly after ECMO (p < 0.01).

CONCLUSION

Microcirculatory parameters are depressed in neonates with severe respiratory failure and improve significantly following ECMO treatment.

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Authors+Show Affiliations

Top AP
Department of Intensive Care, Erasmus Medical Center-Sophia Children's hospital, Rotterdam, The Netherlands. p.top@erasmusmc.nl
Ince C
No affiliation info available
van Dijk M
No affiliation info available
Tibboel D
No affiliation info available

MeSH

Extracorporeal Membrane OxygenationFemaleHumansInfant, NewbornMaleMicrocirculationMouthProspective StudiesRespiratory InsufficiencySeverity of Illness IndexTerm Birth

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19237925

Citation

Top, Anke P C., et al. "Changes in Buccal Microcirculation Following Extracorporeal Membrane Oxygenation in Term Neonates With Severe Respiratory Failure." Critical Care Medicine, vol. 37, no. 3, 2009, pp. 1121-4.
Top AP, Ince C, van Dijk M, et al. Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure. Crit Care Med. 2009;37(3):1121-4.
Top, A. P., Ince, C., van Dijk, M., & Tibboel, D. (2009). Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure. Critical Care Medicine, 37(3), 1121-4. https://doi.org/10.1097/CCM.0b013e3181962a5f
Top AP, et al. Changes in Buccal Microcirculation Following Extracorporeal Membrane Oxygenation in Term Neonates With Severe Respiratory Failure. Crit Care Med. 2009;37(3):1121-4. PubMed PMID: 19237925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure. AU - Top,Anke P C, AU - Ince,Can, AU - van Dijk,Monique, AU - Tibboel,Dick, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/3/26/medline SP - 1121 EP - 4 JF - Critical care medicine JO - Crit Care Med VL - 37 IS - 3 N2 - OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) is known to improve cardiorespiratory function and outcome in neonates with severe respiratory failure. In this study, we tested two hypotheses: 1) neonates with severe respiratory failure exhibit alterations of the microcirculation and 2) after ECMO therapy these microcirculatory alterations are improved. DESIGN: Single-center prospective observational study. SETTING: Intensive care unit of a level III university children's hospital. PATIENTS: Term neonates receiving venoarterial ECMO. Control patients with and without respiratory failure. MEASUREMENTS AND MAIN RESULTS: The microcirculation was assessed in the buccal mucosa, using orthogonal polarization spectral imaging, before and after ECMO. Functional capillary density was lower in patients with severe respiratory failure before ECMO (n = 14) compared with control patients (n = 10; p < 0.01). Functional capillary density had increased significantly after ECMO (p < 0.01). CONCLUSION: Microcirculatory parameters are depressed in neonates with severe respiratory failure and improve significantly following ECMO treatment. SN - 1530-0293 UR - https://www.unboundmedicine.com/medline/citation/19237925/Changes_in_buccal_microcirculation_following_extracorporeal_membrane_oxygenation_in_term_neonates_with_severe_respiratory_failure_ L2 - https://dx.doi.org/10.1097/CCM.0b013e3181962a5f DB - PRIME DP - Unbound Medicine ER -