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Induction dose of propofol in patients using cannabis.

Abstract

BACKGROUND AND OBJECTIVE

An estimated 150 million people worldwide use cannabis. The effect of cannabis on anaesthetic requirements in humans does not appear to have been studied.

METHODS

In this prospective, randomized, single-blinded study, 30 male patients using cannabis more than once per week (group C) and 30 nonusers (group NC), aged 18-50 years, were induced with propofol 1.5, 2, 2.5, 3 or 3.5 mg kg. Additional doses were given when required. The primary outcome was the 50% effective dose of propofol and successful induction was determined by loss of consciousness with a bispectral index value of less than 60 and satisfactory insertion of a laryngeal mask. Propofol requirements to achieve these outcomes were recorded.

RESULTS

The dose required to achieve the target bispectral index value was not significantly higher in group C, but group C required a significantly higher propofol dose to achieve laryngeal mask insertion (314.0 +/- 109.3 vs. 263.2 +/- 69.5 mg, P < 0.04). The estimated effective propofol induction dose in 50-95% of patients did not significantly differ between groups.

CONCLUSION

We conclude that cannabis use increases the propofol dose required for satisfactory clinical induction when inserting a laryngeal mask.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden. per.flisberg@skane.se

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Cannabis
    Depression
    Dose-Response Relationship, Drug
    Humans
    Male
    Middle Aged
    Propofol
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19237981

    Citation

    Flisberg, P, et al. "Induction Dose of Propofol in Patients Using Cannabis." European Journal of Anaesthesiology, vol. 26, no. 3, 2009, pp. 192-5.
    Flisberg P, Paech MJ, Shah T, et al. Induction dose of propofol in patients using cannabis. Eur J Anaesthesiol. 2009;26(3):192-5.
    Flisberg, P., Paech, M. J., Shah, T., Ledowski, T., Kurowski, I., & Parsons, R. (2009). Induction dose of propofol in patients using cannabis. European Journal of Anaesthesiology, 26(3), pp. 192-5. doi:10.1097/EJA.0b013e328319be59.
    Flisberg P, et al. Induction Dose of Propofol in Patients Using Cannabis. Eur J Anaesthesiol. 2009;26(3):192-5. PubMed PMID: 19237981.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Induction dose of propofol in patients using cannabis. AU - Flisberg,P, AU - Paech,M J, AU - Shah,T, AU - Ledowski,T, AU - Kurowski,I, AU - Parsons,R, PY - 2009/2/25/entrez PY - 2009/2/25/pubmed PY - 2009/5/2/medline SP - 192 EP - 5 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 26 IS - 3 N2 - BACKGROUND AND OBJECTIVE: An estimated 150 million people worldwide use cannabis. The effect of cannabis on anaesthetic requirements in humans does not appear to have been studied. METHODS: In this prospective, randomized, single-blinded study, 30 male patients using cannabis more than once per week (group C) and 30 nonusers (group NC), aged 18-50 years, were induced with propofol 1.5, 2, 2.5, 3 or 3.5 mg kg. Additional doses were given when required. The primary outcome was the 50% effective dose of propofol and successful induction was determined by loss of consciousness with a bispectral index value of less than 60 and satisfactory insertion of a laryngeal mask. Propofol requirements to achieve these outcomes were recorded. RESULTS: The dose required to achieve the target bispectral index value was not significantly higher in group C, but group C required a significantly higher propofol dose to achieve laryngeal mask insertion (314.0 +/- 109.3 vs. 263.2 +/- 69.5 mg, P < 0.04). The estimated effective propofol induction dose in 50-95% of patients did not significantly differ between groups. CONCLUSION: We conclude that cannabis use increases the propofol dose required for satisfactory clinical induction when inserting a laryngeal mask. SN - 1365-2346 UR - https://www.unboundmedicine.com/medline/citation/19237981/abstract/Induction_dose_of_propofol_in_patients_using_cannabis_ L2 - http://Insights.ovid.com/pubmed?pmid=19237981 DB - PRIME DP - Unbound Medicine ER -