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The effect of caffeine on postprandial blood pressure in the frail elderly.
Postgrad Med J. 1991 Jun; 67(788):543-7.PM

Abstract

In a double-blind, random-order, cross-over study the effects of placebo and 100 mg of caffeine on postprandial sitting and erect blood pressure and heart rate were studied in 20 frail elderly subjects (mean age 84, range 75-93 years) after a standardized 400 K-calorie glucose drink. Maximal postprandial reduction in sitting systolic blood pressure occurred, at 60 minutes post-placebo, of - 11 mmHg (95% confidence interval -5 to -17 mmHg, P less than 0.01), and was attenuated by caffeine (P less than 0.05) with changes in systolic blood pressure, at 60 minutes post-drink, of 1 mmHg (95% CI -6 to 7 mmHg, not significant). Four subjects developed symptomatic postprandial hypotension after placebo which was prevented by caffeine. There were no significant changes in erect systolic blood pressure, postural systolic blood pressure change, sitting and erect, diastolic blood pressure and heart rate between treatment phases. Caffeine attenuates the postprandial fall in sitting blood pressure in frail elderly subjects and in particular prevented symptomatic blood pressure reductions in subjects with postprandial hypotension.

Authors+Show Affiliations

Department of Medicine for the Elderly, Kingston General Hospital, Hull, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1924023

Citation

Heseltine, D, et al. "The Effect of Caffeine On Postprandial Blood Pressure in the Frail Elderly." Postgraduate Medical Journal, vol. 67, no. 788, 1991, pp. 543-7.
Heseltine D, el-Jabri M, Ahmed F, et al. The effect of caffeine on postprandial blood pressure in the frail elderly. Postgrad Med J. 1991;67(788):543-7.
Heseltine, D., el-Jabri, M., Ahmed, F., & Knox, J. (1991). The effect of caffeine on postprandial blood pressure in the frail elderly. Postgraduate Medical Journal, 67(788), 543-7.
Heseltine D, et al. The Effect of Caffeine On Postprandial Blood Pressure in the Frail Elderly. Postgrad Med J. 1991;67(788):543-7. PubMed PMID: 1924023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of caffeine on postprandial blood pressure in the frail elderly. AU - Heseltine,D, AU - el-Jabri,M, AU - Ahmed,F, AU - Knox,J, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 543 EP - 7 JF - Postgraduate medical journal JO - Postgrad Med J VL - 67 IS - 788 N2 - In a double-blind, random-order, cross-over study the effects of placebo and 100 mg of caffeine on postprandial sitting and erect blood pressure and heart rate were studied in 20 frail elderly subjects (mean age 84, range 75-93 years) after a standardized 400 K-calorie glucose drink. Maximal postprandial reduction in sitting systolic blood pressure occurred, at 60 minutes post-placebo, of - 11 mmHg (95% confidence interval -5 to -17 mmHg, P less than 0.01), and was attenuated by caffeine (P less than 0.05) with changes in systolic blood pressure, at 60 minutes post-drink, of 1 mmHg (95% CI -6 to 7 mmHg, not significant). Four subjects developed symptomatic postprandial hypotension after placebo which was prevented by caffeine. There were no significant changes in erect systolic blood pressure, postural systolic blood pressure change, sitting and erect, diastolic blood pressure and heart rate between treatment phases. Caffeine attenuates the postprandial fall in sitting blood pressure in frail elderly subjects and in particular prevented symptomatic blood pressure reductions in subjects with postprandial hypotension. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/1924023/The_effect_of_caffeine_on_postprandial_blood_pressure_in_the_frail_elderly_ L2 - https://pmj.bmj.com/lookup/pmidlookup?view=long&pmid=1924023 DB - PRIME DP - Unbound Medicine ER -