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T-cell lymphoblastic leukemia/lymphoma presenting in a recurrent thymoma.
Mod Pathol. 1991 Jul; 4(4):524-8.MP

Abstract

A lymphoblastic malignancy presented as the lymphoid component of a recurrent invasive lymphocyte-rich thymoma that had been previously resected and treated with chemotherapy. This high grade lymphoid neoplasm concurrently involved mediastinal nodes and subsequently disseminated to pleural fluid and peripheral blood. Lymphocytes with convoluted nuclei demonstrated a T-lymphoblastic phenotype (UCHL1+, Leu-22+, TdT+) by immunohistochemical studies. T-cell lymphoblastic leukemia/lymphomas in this clinical setting have not been reported, and this case suggests that neoplastic transformation of lymphocytes may occur in longstanding refractory thymomas.

Authors+Show Affiliations

Department of Pathology, Vanderbilt University, Nashville, Tennessee.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1924284

Citation

Macon, W R., et al. "T-cell Lymphoblastic Leukemia/lymphoma Presenting in a Recurrent Thymoma." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 4, no. 4, 1991, pp. 524-8.
Macon WR, Rynalski TH, Swerdlow SH, et al. T-cell lymphoblastic leukemia/lymphoma presenting in a recurrent thymoma. Mod Pathol. 1991;4(4):524-8.
Macon, W. R., Rynalski, T. H., Swerdlow, S. H., & Cousar, J. B. (1991). T-cell lymphoblastic leukemia/lymphoma presenting in a recurrent thymoma. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 4(4), 524-8.
Macon WR, et al. T-cell Lymphoblastic Leukemia/lymphoma Presenting in a Recurrent Thymoma. Mod Pathol. 1991;4(4):524-8. PubMed PMID: 1924284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T-cell lymphoblastic leukemia/lymphoma presenting in a recurrent thymoma. AU - Macon,W R, AU - Rynalski,T H, AU - Swerdlow,S H, AU - Cousar,J B, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 524 EP - 8 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 4 IS - 4 N2 - A lymphoblastic malignancy presented as the lymphoid component of a recurrent invasive lymphocyte-rich thymoma that had been previously resected and treated with chemotherapy. This high grade lymphoid neoplasm concurrently involved mediastinal nodes and subsequently disseminated to pleural fluid and peripheral blood. Lymphocytes with convoluted nuclei demonstrated a T-lymphoblastic phenotype (UCHL1+, Leu-22+, TdT+) by immunohistochemical studies. T-cell lymphoblastic leukemia/lymphomas in this clinical setting have not been reported, and this case suggests that neoplastic transformation of lymphocytes may occur in longstanding refractory thymomas. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/1924284/T_cell_lymphoblastic_leukemia/lymphoma_presenting_in_a_recurrent_thymoma_ L2 - http://RD3FS2PT9J.search.serialssolutions.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqm&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&issn=0893-3952&eissn=1530-0285&volume=4&issue=4&spage=524&date=1991 DB - PRIME DP - Unbound Medicine ER -