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Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems.
Diabetes Technol Ther. 2009 Feb; 11(2):65-72.DT

Abstract

OBJECTIVE

This study evaluated the accuracy and safety of two continuous glucose monitoring (CGM) systems, the SEVEN (DexCom, San Diego, CA) and the Navigator (Abbott Diabetes Care, Alameda, CA), with the YSI laboratory measurements of blood glucose (blood glucose meter manufactured by YSI, Yellow Springs, OH), when worn concurrently in adults with type 1 diabetes.

DESIGN AND METHODS

Fourteen subjects with type 1 diabetes, 33 +/- 6 (mean +/- SD) years old, were enrolled in this study. All subjects wore both sensors concurrently over three consecutive 5-day CGM sessions (15-day wear). On Days 5, 10, and 15, subjects participated in an 8-h in-clinic session where measurements from the CGM systems were collected and compared with YSI measurements every 15 min. At the end of Day 5 and 10 in-clinic sessions, the sensors were removed, and new sensors were inserted for the following CGM session despite the SEVEN system's recommended use for up to 7 days.

RESULTS

The mean absolute relative difference (ARD) for the two CGM devices versus YSI was not different: 16.8% and 16.1% for SEVEN and Navigator, respectively (P = 0.38). In the hypoglycemic region (YSI value <80 mg/dL), the mean ARD for SEVEN was lower than for Navigator (21.5% vs. 29.8%, respectively; P = 0.001). The data analyses were similar when compared with self-monitoring of blood glucose (SMBG) values. Thirteen additional Navigator replacement devices were issued compared to two for the SEVEN. A total of three versus 14 skin reactions were reported with the SEVEN and Navigator insertion area, respectively.

CONCLUSIONS

Glucose measurements with the SEVEN and Navigator were found to be similar compared with YSI and SMBG measurements, with the exception of the hypoglycemic range where the SEVEN performed better. However, the Navigator caused more skin area reactions.

Authors+Show Affiliations

Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado at Denver, Aurora, Colorado 80045, USA. satish.garg@ucdenver.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19243265

Citation

Garg, Satish K., et al. "Comparison of Accuracy and Safety of the SEVEN and the Navigator Continuous Glucose Monitoring Systems." Diabetes Technology & Therapeutics, vol. 11, no. 2, 2009, pp. 65-72.
Garg SK, Smith J, Beatson C, et al. Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems. Diabetes Technol Ther. 2009;11(2):65-72.
Garg, S. K., Smith, J., Beatson, C., Lopez-Baca, B., Voelmle, M., & Gottlieb, P. A. (2009). Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems. Diabetes Technology & Therapeutics, 11(2), 65-72. https://doi.org/10.1089/dia.2008.0109
Garg SK, et al. Comparison of Accuracy and Safety of the SEVEN and the Navigator Continuous Glucose Monitoring Systems. Diabetes Technol Ther. 2009;11(2):65-72. PubMed PMID: 19243265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems. AU - Garg,Satish K, AU - Smith,James, AU - Beatson,Christie, AU - Lopez-Baca,Benita, AU - Voelmle,Mary, AU - Gottlieb,Peter A, PY - 2009/2/27/entrez PY - 2009/2/27/pubmed PY - 2010/4/29/medline SP - 65 EP - 72 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 11 IS - 2 N2 - OBJECTIVE: This study evaluated the accuracy and safety of two continuous glucose monitoring (CGM) systems, the SEVEN (DexCom, San Diego, CA) and the Navigator (Abbott Diabetes Care, Alameda, CA), with the YSI laboratory measurements of blood glucose (blood glucose meter manufactured by YSI, Yellow Springs, OH), when worn concurrently in adults with type 1 diabetes. DESIGN AND METHODS: Fourteen subjects with type 1 diabetes, 33 +/- 6 (mean +/- SD) years old, were enrolled in this study. All subjects wore both sensors concurrently over three consecutive 5-day CGM sessions (15-day wear). On Days 5, 10, and 15, subjects participated in an 8-h in-clinic session where measurements from the CGM systems were collected and compared with YSI measurements every 15 min. At the end of Day 5 and 10 in-clinic sessions, the sensors were removed, and new sensors were inserted for the following CGM session despite the SEVEN system's recommended use for up to 7 days. RESULTS: The mean absolute relative difference (ARD) for the two CGM devices versus YSI was not different: 16.8% and 16.1% for SEVEN and Navigator, respectively (P = 0.38). In the hypoglycemic region (YSI value <80 mg/dL), the mean ARD for SEVEN was lower than for Navigator (21.5% vs. 29.8%, respectively; P = 0.001). The data analyses were similar when compared with self-monitoring of blood glucose (SMBG) values. Thirteen additional Navigator replacement devices were issued compared to two for the SEVEN. A total of three versus 14 skin reactions were reported with the SEVEN and Navigator insertion area, respectively. CONCLUSIONS: Glucose measurements with the SEVEN and Navigator were found to be similar compared with YSI and SMBG measurements, with the exception of the hypoglycemic range where the SEVEN performed better. However, the Navigator caused more skin area reactions. SN - 1520-9156 UR - https://www.unboundmedicine.com/medline/citation/19243265/Comparison_of_accuracy_and_safety_of_the_SEVEN_and_the_Navigator_continuous_glucose_monitoring_systems_ L2 - https://www.liebertpub.com/doi/10.1089/dia.2008.0109?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -