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Metabolic disturbances in non-alcoholic fatty liver disease.
Clin Sci (Lond) 2009; 116(7):539-64CS

Abstract

NAFLD (non-alcoholic fatty liver disease) refers to a wide spectrum of liver damage, ranging from simple steatosis to NASH (non-alcoholic steatohepatitis), advanced fibrosis and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple non-invasive diagnostic tests to facilitate an estimate of prevalence. In certain subgroups of patients, such as those with Type 2 diabetes, the prevalence of NAFLD, defined by ultrasound, may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH and, in particular, to develop strategies for interventions to treat this condition. Currently, the 'gold standard' for the diagnosis of NASH is liver biopsy, and the need to undertake a biopsy has impeded research in subjects in this field. Limited results suggest that the prevalence of NASH could be as high as 11% in the general population, suggesting there is a worsening future public health problem in this field of medicine. With a burgeoning epidemic of diabetes in an aging population, it is likely that the prevalence of NASH will continue to increase over time as both factors are important risk factors for liver fibrosis. The purpose of this review is to: (i) briefly discuss the epidemiology of NAFLD to describe the magnitude of the future potential public health problem; and (ii) to discuss extra- and intra-hepatic mechanisms contributing to the pathogenesis of NAFLD, a better understanding of which may help in the development of novel treatments for this condition.

Authors+Show Affiliations

Endocrinology & Metabolism Unit, Institute for Developmental Sciences, University of Southampton and Southampton University Hospitals Trust, Southampton General Hospital, Southampton SO16 6YD, UK. cdtb@southampton.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19243311

Citation

Byrne, Christopher D., et al. "Metabolic Disturbances in Non-alcoholic Fatty Liver Disease." Clinical Science (London, England : 1979), vol. 116, no. 7, 2009, pp. 539-64.
Byrne CD, Olufadi R, Bruce KD, et al. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci. 2009;116(7):539-64.
Byrne, C. D., Olufadi, R., Bruce, K. D., Cagampang, F. R., & Ahmed, M. H. (2009). Metabolic disturbances in non-alcoholic fatty liver disease. Clinical Science (London, England : 1979), 116(7), pp. 539-64. doi:10.1042/CS20080253.
Byrne CD, et al. Metabolic Disturbances in Non-alcoholic Fatty Liver Disease. Clin Sci. 2009;116(7):539-64. PubMed PMID: 19243311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic disturbances in non-alcoholic fatty liver disease. AU - Byrne,Christopher D, AU - Olufadi,Rasaq, AU - Bruce,Kimberley D, AU - Cagampang,Felino R, AU - Ahmed,Mohamed H, PY - 2009/2/27/entrez PY - 2009/2/27/pubmed PY - 2009/5/15/medline SP - 539 EP - 64 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 116 IS - 7 N2 - NAFLD (non-alcoholic fatty liver disease) refers to a wide spectrum of liver damage, ranging from simple steatosis to NASH (non-alcoholic steatohepatitis), advanced fibrosis and cirrhosis. NAFLD is strongly associated with insulin resistance and is defined by accumulation of liver fat >5% per liver weight in the presence of <10 g of daily alcohol consumption. The exact prevalence of NAFLD is uncertain because of the absence of simple non-invasive diagnostic tests to facilitate an estimate of prevalence. In certain subgroups of patients, such as those with Type 2 diabetes, the prevalence of NAFLD, defined by ultrasound, may be as high as 70%. NASH is an important subgroup within the spectrum of NAFLD that progresses over time with worsening fibrosis and cirrhosis, and is associated with increased risk for cardiovascular disease. It is, therefore, important to understand the pathogenesis of NASH and, in particular, to develop strategies for interventions to treat this condition. Currently, the 'gold standard' for the diagnosis of NASH is liver biopsy, and the need to undertake a biopsy has impeded research in subjects in this field. Limited results suggest that the prevalence of NASH could be as high as 11% in the general population, suggesting there is a worsening future public health problem in this field of medicine. With a burgeoning epidemic of diabetes in an aging population, it is likely that the prevalence of NASH will continue to increase over time as both factors are important risk factors for liver fibrosis. The purpose of this review is to: (i) briefly discuss the epidemiology of NAFLD to describe the magnitude of the future potential public health problem; and (ii) to discuss extra- and intra-hepatic mechanisms contributing to the pathogenesis of NAFLD, a better understanding of which may help in the development of novel treatments for this condition. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/19243311/Metabolic_disturbances_in_non_alcoholic_fatty_liver_disease_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20080253 DB - PRIME DP - Unbound Medicine ER -