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Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care--a 5-year follow-up.
Aliment Pharmacol Ther 2009; 29(11):1172-8AP

Abstract

BACKGROUND

Gastro-oesophageal reflux disease (GERD) can be associated with laryngo-respiratory symptoms (LRS) such as chronic cough, asthma or laryngeal symptoms.

AIM

To analyse the long-term clinical course of LRS in a large population with GERD and LRS.

METHODS

ProGERD is a prospective multicentre cohort study of 6215 adult out-patients with GERD. At baseline, the prevalence of LRS was assessed. Initial standardized treatment was esomeprazole for up to 8 weeks. After 5 years of follow-up, patients were interviewed for LRS and a multivariate analysis was performed with resolved vs. persistent symptoms for chronic cough, asthma and laryngeal symptoms.

RESULTS

In all, 2886 patients (46.4%) were available for analysis at baseline and at 5 years. The prevalence of chronic cough and laryngeal disorders had decreased while the prevalence of asthma had increased. Resolution of LRS was independent of clinical reflux characteristics or PPI medication.

CONCLUSIONS

In a large population with GERD, only few patients reported persistent LRS over 5 years. Resolution of LRS was independent of the stage of GERD and PPI treatment. Accordingly, data on the direction of causality between GERD and LRS are lacking and the strength of the association between the two must remain controversial.

Authors+Show Affiliations

Med.Klinik II, Klinikum Fulda, Pacelliallee 4-6, Fulda, Germany. d.jaspersen.medII@klinikum-fulda.de

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19243356

Citation

Jaspersen, D, et al. "Clinical Course of Laryngo-respiratory Symptoms in Gastro-oesophageal Reflux Disease During Routine Care--a 5-year Follow-up." Alimentary Pharmacology & Therapeutics, vol. 29, no. 11, 2009, pp. 1172-8.
Jaspersen D, Nocon M, Labenz J, et al. Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care--a 5-year follow-up. Aliment Pharmacol Ther. 2009;29(11):1172-8.
Jaspersen, D., Nocon, M., Labenz, J., Leodolter, A., Richter, K., Stolte, M., ... Malfertheiner, P. (2009). Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care--a 5-year follow-up. Alimentary Pharmacology & Therapeutics, 29(11), pp. 1172-8. doi:10.1111/j.1365-2036.2009.03981.x.
Jaspersen D, et al. Clinical Course of Laryngo-respiratory Symptoms in Gastro-oesophageal Reflux Disease During Routine Care--a 5-year Follow-up. Aliment Pharmacol Ther. 2009 Jun 1;29(11):1172-8. PubMed PMID: 19243356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care--a 5-year follow-up. AU - Jaspersen,D, AU - Nocon,M, AU - Labenz,J, AU - Leodolter,A, AU - Richter,K, AU - Stolte,M, AU - Vieth,M, AU - Lind,T, AU - Willich,S N, AU - Malfertheiner,P, Y1 - 2009/02/23/ PY - 2009/2/27/entrez PY - 2009/2/27/pubmed PY - 2010/2/23/medline SP - 1172 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 29 IS - 11 N2 - BACKGROUND: Gastro-oesophageal reflux disease (GERD) can be associated with laryngo-respiratory symptoms (LRS) such as chronic cough, asthma or laryngeal symptoms. AIM: To analyse the long-term clinical course of LRS in a large population with GERD and LRS. METHODS: ProGERD is a prospective multicentre cohort study of 6215 adult out-patients with GERD. At baseline, the prevalence of LRS was assessed. Initial standardized treatment was esomeprazole for up to 8 weeks. After 5 years of follow-up, patients were interviewed for LRS and a multivariate analysis was performed with resolved vs. persistent symptoms for chronic cough, asthma and laryngeal symptoms. RESULTS: In all, 2886 patients (46.4%) were available for analysis at baseline and at 5 years. The prevalence of chronic cough and laryngeal disorders had decreased while the prevalence of asthma had increased. Resolution of LRS was independent of clinical reflux characteristics or PPI medication. CONCLUSIONS: In a large population with GERD, only few patients reported persistent LRS over 5 years. Resolution of LRS was independent of the stage of GERD and PPI treatment. Accordingly, data on the direction of causality between GERD and LRS are lacking and the strength of the association between the two must remain controversial. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19243356/Clinical_course_of_laryngo_respiratory_symptoms_in_gastro_oesophageal_reflux_disease_during_routine_care__a_5_year_follow_up_ L2 - https://doi.org/10.1111/j.1365-2036.2009.03981.x DB - PRIME DP - Unbound Medicine ER -