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Kaempferol, a mutagenic flavonol from Helichrysum simillimum.
Hum Exp Toxicol. 2008 Nov; 27(11):845-9.HE

Abstract

Helichrysum simillimum is native to South Africa. It is used for the treatment of coughs, colds, fever, infections, headache, and menstrual pain. Extracts of this species showed mutagenic effects in the Salmonella/microsome assay. The aim of this study was to isolate and determine the mutagenic constituents of H. simillimum. Bioassay-guided fractionation of 90% aqueous methanol extracts, using Salmonella typhimurium TA98, led to the isolation of the flavonol kaempferol.

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Authors+Show Affiliations

Elgorashi E
Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa.
van Heerden F
No affiliation info available
van Staden J
No affiliation info available

MeSH

AnimalsApoptosisCells, CulturedHelichrysumIn Vitro TechniquesKaempferolsMethanolMutagenicity TestsMutagensPlant ExtractsRatsSalmonella typhimuriumSolvents

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19244292

Citation

Elgorashi, Ee, et al. "Kaempferol, a Mutagenic Flavonol From Helichrysum Simillimum." Human & Experimental Toxicology, vol. 27, no. 11, 2008, pp. 845-9.
Elgorashi E, van Heerden F, van Staden J. Kaempferol, a mutagenic flavonol from Helichrysum simillimum. Hum Exp Toxicol. 2008;27(11):845-9.
Elgorashi, E., van Heerden, F., & van Staden, J. (2008). Kaempferol, a mutagenic flavonol from Helichrysum simillimum. Human & Experimental Toxicology, 27(11), 845-9. https://doi.org/10.1177/0960327108099532
Elgorashi E, van Heerden F, van Staden J. Kaempferol, a Mutagenic Flavonol From Helichrysum Simillimum. Hum Exp Toxicol. 2008;27(11):845-9. PubMed PMID: 19244292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kaempferol, a mutagenic flavonol from Helichrysum simillimum. AU - Elgorashi,Ee, AU - van Heerden,Fr, AU - van Staden,J, PY - 2009/2/27/entrez PY - 2009/2/27/pubmed PY - 2009/5/9/medline SP - 845 EP - 9 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 27 IS - 11 N2 - Helichrysum simillimum is native to South Africa. It is used for the treatment of coughs, colds, fever, infections, headache, and menstrual pain. Extracts of this species showed mutagenic effects in the Salmonella/microsome assay. The aim of this study was to isolate and determine the mutagenic constituents of H. simillimum. Bioassay-guided fractionation of 90% aqueous methanol extracts, using Salmonella typhimurium TA98, led to the isolation of the flavonol kaempferol. SN - 0960-3271 UR - https://www.unboundmedicine.com/medline/citation/19244292/Kaempferol_a_mutagenic_flavonol_from_Helichrysum_simillimum_ L2 - https://journals.sagepub.com/doi/10.1177/0960327108099532?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -