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Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction.
Am J Clin Nutr. 2009 Apr; 89(4):1263-8.AJ

Abstract

BACKGROUND

The relation between vitamin B-12 and cognitive function in older adults is unclear. Limited evidence suggests that the relation is modulated by apolipoprotein E epsilon4. Hence, it is important to further examine this gene-nutrient interaction.

OBJECTIVE

The aim was to investigate the role of apolipoprotein E (APOE) epsilon4 as a genetic predisposing factor modulating the effect of vitamin B-12 on cognitive function.

DESIGN

A battery of neuropsychological tests, including the Mini-Mental State Examination (MMSE) for global cognition, was administered at the baseline assessment to 539 Chinese adults aged > or =55 y. The MMSE was repeated at a median 18 mo (n = 376) and a median of 38 mo (n = 247) after baseline. The interaction of vitamin B-12 and APOE epsilon4 on cognitive function was examined in a linear mixed-effects model for MMSE and in a multiple linear regression model for neuropsychological test scores.

RESULTS

APOE epsilon4 was associated with a lower MMSE score. Vitamin B-12 (natural log transformed) was positively related to MMSE score, and this association was much stronger in APOE epsilon4 carriers than in APOE epsilon4 noncarriers (P for interaction = 0.016). Significant interactions between natural log-transformed vitamin B-12 and APOE epsilon4 were also found for the Digit Span Backward Longest Sequence (P for interaction = 0.013) and Rey Auditory Verbal Learning Test immediate recall (P for interaction = 0.005). Better performance in these 2 tests was associated with vitamin B-12 in APOE epsilon4 carriers but not in APOE epsilon4 noncarriers.

CONCLUSION

The association between vitamin B-12 and cognitive function was moderated by APOE epsilon4 status.

Authors+Show Affiliations

Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. pcmfl@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19244370

Citation

Feng, Lei, et al. "Vitamin B-12, Apolipoprotein E Genotype, and Cognitive Performance in Community-living Older Adults: Evidence of a Gene-micronutrient Interaction." The American Journal of Clinical Nutrition, vol. 89, no. 4, 2009, pp. 1263-8.
Feng L, Li J, Yap KB, et al. Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction. Am J Clin Nutr. 2009;89(4):1263-8.
Feng, L., Li, J., Yap, K. B., Kua, E. H., & Ng, T. P. (2009). Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction. The American Journal of Clinical Nutrition, 89(4), 1263-8. https://doi.org/10.3945/ajcn.2008.26969
Feng L, et al. Vitamin B-12, Apolipoprotein E Genotype, and Cognitive Performance in Community-living Older Adults: Evidence of a Gene-micronutrient Interaction. Am J Clin Nutr. 2009;89(4):1263-8. PubMed PMID: 19244370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a gene-micronutrient interaction. AU - Feng,Lei, AU - Li,Jialiang, AU - Yap,Keng-Bee, AU - Kua,Ee-Heok, AU - Ng,Tze-Pin, Y1 - 2009/02/25/ PY - 2009/2/27/entrez PY - 2009/2/27/pubmed PY - 2009/4/7/medline SP - 1263 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 89 IS - 4 N2 - BACKGROUND: The relation between vitamin B-12 and cognitive function in older adults is unclear. Limited evidence suggests that the relation is modulated by apolipoprotein E epsilon4. Hence, it is important to further examine this gene-nutrient interaction. OBJECTIVE: The aim was to investigate the role of apolipoprotein E (APOE) epsilon4 as a genetic predisposing factor modulating the effect of vitamin B-12 on cognitive function. DESIGN: A battery of neuropsychological tests, including the Mini-Mental State Examination (MMSE) for global cognition, was administered at the baseline assessment to 539 Chinese adults aged > or =55 y. The MMSE was repeated at a median 18 mo (n = 376) and a median of 38 mo (n = 247) after baseline. The interaction of vitamin B-12 and APOE epsilon4 on cognitive function was examined in a linear mixed-effects model for MMSE and in a multiple linear regression model for neuropsychological test scores. RESULTS: APOE epsilon4 was associated with a lower MMSE score. Vitamin B-12 (natural log transformed) was positively related to MMSE score, and this association was much stronger in APOE epsilon4 carriers than in APOE epsilon4 noncarriers (P for interaction = 0.016). Significant interactions between natural log-transformed vitamin B-12 and APOE epsilon4 were also found for the Digit Span Backward Longest Sequence (P for interaction = 0.013) and Rey Auditory Verbal Learning Test immediate recall (P for interaction = 0.005). Better performance in these 2 tests was associated with vitamin B-12 in APOE epsilon4 carriers but not in APOE epsilon4 noncarriers. CONCLUSION: The association between vitamin B-12 and cognitive function was moderated by APOE epsilon4 status. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19244370/Vitamin_B_12_apolipoprotein_E_genotype_and_cognitive_performance_in_community_living_older_adults:_evidence_of_a_gene_micronutrient_interaction_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26969 DB - PRIME DP - Unbound Medicine ER -