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The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters.
APMIS. 2009 Mar; 117(3):162-75.A

Abstract

This study aimed to evaluate the relationship of fascin-1, matrix metalloproteinase (MMP)-2, MMP-9, cortactin, survivin, and epidermal growth factor receptor (EGFR) expression with clinicopathological parameters for the four most common ovarian surface epithelial carcinomas. Six biomarkers were investigated immunohistochemically using tissue microarrays of 185 specimens including 79 serous cystadenocarcinomas, 47 mucinous cystadenocarcinomas, 45 endometrioid adenocarcinomas, and 14 clear cell carcinomas. The four most common ovarian carcinomas showed significant expression of fascin-1, cortactin, survivin, and EGFR, but not of MMP-2 and MMP-9. In addition, higher immunostaining scores for fascin-1 in mucinous cystadenocarcinomas correlated with T stage, N stage, American Joint Committee on Cancer AJCC clinical stage, and a poorer survival rate; for cortactin in serous cystadenocarcinomas correlated with T stage; for cortactin in clear cell carcinomas correlated with T and clinical AJCC stages; and for survivin in clear cell carcinomas correlated with T stage and AJCC clinical stage. In addition, higher immunostaining scores for fascin-1, cortactin, and survivin correlated with poorer tumor differentiation in serous, mucinous, and endometrioid adenocarcinomas. Thus, the expression of fascin-1, cortactin, and survivin may be helpful in evaluating the aggressiveness of ovarian mucinous, serous, and clear cell adenocarcinoma. Additionally, the expression of fascin-1 may be an independent prognostic risk factor in mucinous cystadenocarcinoma.

Authors+Show Affiliations

Department of Pathology, Tri-Service General Hospital, National Defence Medical Center, No. 325 Sec. 2 Cheng-Gong Road, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19245589

Citation

Lin, Chih-Kung, et al. "The Expression of Six Biomarkers in the Four Most Common Ovarian Cancers: Correlation With Clinicopathological Parameters." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 117, no. 3, 2009, pp. 162-75.
Lin CK, Chao TK, Yu CP, et al. The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS. 2009;117(3):162-75.
Lin, C. K., Chao, T. K., Yu, C. P., Yu, M. H., & Jin, J. S. (2009). The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 117(3), 162-75. https://doi.org/10.1111/j.1600-0463.2008.00003.x
Lin CK, et al. The Expression of Six Biomarkers in the Four Most Common Ovarian Cancers: Correlation With Clinicopathological Parameters. APMIS. 2009;117(3):162-75. PubMed PMID: 19245589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. AU - Lin,Chih-Kung, AU - Chao,Tai-Kuang, AU - Yu,Cheng-Ping, AU - Yu,Mu-Hsien, AU - Jin,Jong-Shiaw, PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2009/4/8/medline SP - 162 EP - 75 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 117 IS - 3 N2 - This study aimed to evaluate the relationship of fascin-1, matrix metalloproteinase (MMP)-2, MMP-9, cortactin, survivin, and epidermal growth factor receptor (EGFR) expression with clinicopathological parameters for the four most common ovarian surface epithelial carcinomas. Six biomarkers were investigated immunohistochemically using tissue microarrays of 185 specimens including 79 serous cystadenocarcinomas, 47 mucinous cystadenocarcinomas, 45 endometrioid adenocarcinomas, and 14 clear cell carcinomas. The four most common ovarian carcinomas showed significant expression of fascin-1, cortactin, survivin, and EGFR, but not of MMP-2 and MMP-9. In addition, higher immunostaining scores for fascin-1 in mucinous cystadenocarcinomas correlated with T stage, N stage, American Joint Committee on Cancer AJCC clinical stage, and a poorer survival rate; for cortactin in serous cystadenocarcinomas correlated with T stage; for cortactin in clear cell carcinomas correlated with T and clinical AJCC stages; and for survivin in clear cell carcinomas correlated with T stage and AJCC clinical stage. In addition, higher immunostaining scores for fascin-1, cortactin, and survivin correlated with poorer tumor differentiation in serous, mucinous, and endometrioid adenocarcinomas. Thus, the expression of fascin-1, cortactin, and survivin may be helpful in evaluating the aggressiveness of ovarian mucinous, serous, and clear cell adenocarcinoma. Additionally, the expression of fascin-1 may be an independent prognostic risk factor in mucinous cystadenocarcinoma. SN - 1600-0463 UR - https://www.unboundmedicine.com/medline/citation/19245589/The_expression_of_six_biomarkers_in_the_four_most_common_ovarian_cancers:_correlation_with_clinicopathological_parameters_ L2 - https://doi.org/10.1111/j.1600-0463.2008.00003.x DB - PRIME DP - Unbound Medicine ER -