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AMPK activators--potential therapeutics for metabolic and other diseases.
Acta Physiol (Oxf). 2009 May; 196(1):175-90.AP

Abstract

AMP-activated protein kinase (AMPK)-mediated cellular metabolic responses to tissue-specific and whole-body stimuli play a vital role in the control of energy homeostasis. As a cellular energy-sensing mechanism, AMPK activation stimulates glucose uptake and fat oxidation, while it suppresses lipogenesis and gluconeogenesis. The cumulative effects of AMPK activation lead to beneficial metabolic states in liver, muscle and other peripheral tissues that are critical in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders. Activators of AMPK that target selected tissues hold potential as novel therapeutics for diseases in which altered energy metabolism contributes to aetiology.

Authors+Show Affiliations

Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19245659

Citation

Zhou, G, et al. "AMPK Activators--potential Therapeutics for Metabolic and Other Diseases." Acta Physiologica (Oxford, England), vol. 196, no. 1, 2009, pp. 175-90.
Zhou G, Sebhat IK, Zhang BB. AMPK activators--potential therapeutics for metabolic and other diseases. Acta Physiol (Oxf). 2009;196(1):175-90.
Zhou, G., Sebhat, I. K., & Zhang, B. B. (2009). AMPK activators--potential therapeutics for metabolic and other diseases. Acta Physiologica (Oxford, England), 196(1), 175-90. https://doi.org/10.1111/j.1748-1716.2009.01967.x
Zhou G, Sebhat IK, Zhang BB. AMPK Activators--potential Therapeutics for Metabolic and Other Diseases. Acta Physiol (Oxf). 2009;196(1):175-90. PubMed PMID: 19245659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - AMPK activators--potential therapeutics for metabolic and other diseases. AU - Zhou,G, AU - Sebhat,I K, AU - Zhang,B B, Y1 - 2009/02/19/ PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2010/3/13/medline SP - 175 EP - 90 JF - Acta physiologica (Oxford, England) JO - Acta Physiol (Oxf) VL - 196 IS - 1 N2 - AMP-activated protein kinase (AMPK)-mediated cellular metabolic responses to tissue-specific and whole-body stimuli play a vital role in the control of energy homeostasis. As a cellular energy-sensing mechanism, AMPK activation stimulates glucose uptake and fat oxidation, while it suppresses lipogenesis and gluconeogenesis. The cumulative effects of AMPK activation lead to beneficial metabolic states in liver, muscle and other peripheral tissues that are critical in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders. Activators of AMPK that target selected tissues hold potential as novel therapeutics for diseases in which altered energy metabolism contributes to aetiology. SN - 1748-1716 UR - https://www.unboundmedicine.com/medline/citation/19245659/AMPK_activators__potential_therapeutics_for_metabolic_and_other_diseases_ L2 - https://doi.org/10.1111/j.1748-1716.2009.01967.x DB - PRIME DP - Unbound Medicine ER -