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Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium.
Carbohydr Res. 2009 Mar 31; 344(5):699-706.CR

Abstract

pH-Sensitive semi-interpenetrating networks (IPNs) based on chitosan (Cs) and acrylamide-grafted hydroxyethylcellulose (AAm-g-HEC) were prepared in the form of microspheres (MPs) by emulsion-crosslinking technique using glutaraldehyde (GA) as a crosslinker. Diclofenac sodium (DS) drug was successfully encapsulated into IPN microspheres by varying the ratio of Cs and AAm-g-HEC, % drug loading, and amount of GA. DS encapsulation of up to 83% was obtained as measured by UV spectroscopy. MPs with average particle sizes in the range of 188-310microm were obtained. MPs were characterized by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Differential scanning calorimetry (DSC). Diffusion coefficients (D) of water transport through the microspheres were determined using an empirical equation. In vitro release of DS from these matrices has been investigated in pH 1.2 and 7.4 media.

Authors+Show Affiliations

Department of Industrial Chemistry, Kuvempu University, School of Chemical Science, Jnana Sahyadri, Shankaraghatta 577 451, Karnataka, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19246032

Citation

Al-Kahtani Ahmed, A, et al. "Synthesis and Characterization of Chitosan-based pH-sensitive Semi-interpenetrating Network Microspheres for Controlled Release of Diclofenac Sodium." Carbohydrate Research, vol. 344, no. 5, 2009, pp. 699-706.
Al-Kahtani Ahmed A, Bhojya Naik HS, Sherigara BS. Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium. Carbohydr Res. 2009;344(5):699-706.
Al-Kahtani Ahmed, A., Bhojya Naik, H. S., & Sherigara, B. S. (2009). Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium. Carbohydrate Research, 344(5), 699-706. https://doi.org/10.1016/j.carres.2009.01.011
Al-Kahtani Ahmed A, Bhojya Naik HS, Sherigara BS. Synthesis and Characterization of Chitosan-based pH-sensitive Semi-interpenetrating Network Microspheres for Controlled Release of Diclofenac Sodium. Carbohydr Res. 2009 Mar 31;344(5):699-706. PubMed PMID: 19246032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and characterization of chitosan-based pH-sensitive semi-interpenetrating network microspheres for controlled release of diclofenac sodium. AU - Al-Kahtani Ahmed,A, AU - Bhojya Naik,H S, AU - Sherigara,B S, Y1 - 2009/01/19/ PY - 2008/07/09/received PY - 2008/12/27/revised PY - 2009/01/13/accepted PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2009/5/13/medline SP - 699 EP - 706 JF - Carbohydrate research JO - Carbohydr. Res. VL - 344 IS - 5 N2 - pH-Sensitive semi-interpenetrating networks (IPNs) based on chitosan (Cs) and acrylamide-grafted hydroxyethylcellulose (AAm-g-HEC) were prepared in the form of microspheres (MPs) by emulsion-crosslinking technique using glutaraldehyde (GA) as a crosslinker. Diclofenac sodium (DS) drug was successfully encapsulated into IPN microspheres by varying the ratio of Cs and AAm-g-HEC, % drug loading, and amount of GA. DS encapsulation of up to 83% was obtained as measured by UV spectroscopy. MPs with average particle sizes in the range of 188-310microm were obtained. MPs were characterized by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Differential scanning calorimetry (DSC). Diffusion coefficients (D) of water transport through the microspheres were determined using an empirical equation. In vitro release of DS from these matrices has been investigated in pH 1.2 and 7.4 media. SN - 1873-426X UR - https://www.unboundmedicine.com/medline/citation/19246032/Synthesis_and_characterization_of_chitosan_based_pH_sensitive_semi_interpenetrating_network_microspheres_for_controlled_release_of_diclofenac_sodium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-6215(09)00012-3 DB - PRIME DP - Unbound Medicine ER -