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Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba.
Bioorg Med Chem Lett. 2009 Mar 15; 19(6):1572-4.BM

Abstract

A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.

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Authors+Show Affiliations

Qin JC
College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
Zhang YM
No affiliation info available
Gao JM
No affiliation info available
Bai MS
No affiliation info available
Yang SX
No affiliation info available
Laatsch H
No affiliation info available
Zhang AL
No affiliation info available

MeSH

AnimalsArtemiaBiological AssayChaetomiumChemistry, PharmaceuticalDrug Evaluation, PreclinicalFungal ProteinsFuransGinkgo bilobaIndole AlkaloidsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsModels, ChemicalMolecular StructurePyronesRhizobium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19246197

Citation

Qin, Jian-Chun, et al. "Bioactive Metabolites Produced By Chaetomium Globosum, an Endophytic Fungus Isolated From Ginkgo Biloba." Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 6, 2009, pp. 1572-4.
Qin JC, Zhang YM, Gao JM, et al. Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorg Med Chem Lett. 2009;19(6):1572-4.
Qin, J. C., Zhang, Y. M., Gao, J. M., Bai, M. S., Yang, S. X., Laatsch, H., & Zhang, A. L. (2009). Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorganic & Medicinal Chemistry Letters, 19(6), 1572-4. https://doi.org/10.1016/j.bmcl.2009.02.025
Qin JC, et al. Bioactive Metabolites Produced By Chaetomium Globosum, an Endophytic Fungus Isolated From Ginkgo Biloba. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1572-4. PubMed PMID: 19246197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. AU - Qin,Jian-Chun, AU - Zhang,Ya-Mei, AU - Gao,Jin-Ming, AU - Bai,Ming-Sheng, AU - Yang,Sheng-Xiang, AU - Laatsch,Hartmut, AU - Zhang,An-Ling, Y1 - 2009/02/11/ PY - 2008/12/01/received PY - 2009/01/31/revised PY - 2009/02/06/accepted PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2009/8/21/medline SP - 1572 EP - 4 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 19 IS - 6 N2 - A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/19246197/Bioactive_metabolites_produced_by_Chaetomium_globosum_an_endophytic_fungus_isolated_from_Ginkgo_biloba_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(09)00169-3 DB - PRIME DP - Unbound Medicine ER -