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Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk.
Dement Geriatr Cogn Disord. 2009; 27(3):286-91.DG

Abstract

BACKGROUND/AIM

Interleukin-8 (IL-8), a potent chemoattractant for neutrophils, has been implicated in the pathogenesis of Alzheimer's disease (AD). The ability of individuals to produce high levels of IL-8 is partially determined by the IL-8 -251 T/A polymorphism. Therefore, we investigated the association between this polymorphism and AD in a Chinese population. Additionally, in light of the stimulatory effect of homocysteine on the production of IL-8, we also sought to determine whether the methylenetetrahydrofolate reductase (MTHFR) gene 677 C/T variant, a genetic modifier of the serum homocysteine level, may interact with the IL-8 -251 polymorphism in determining the AD risk.

METHODS

Genotyping of 198 AD patients and 240 matched controls was performed by PCR-RFLP.

RESULTS

The presence of the MTHFR 677 C/T and 677 T/T genotypes conferred a marginally significant increase in the risk for AD (OR = 1.666, 95% CI = 1.022-2.715, and OR = 1.892, 95% CI = 1.124-3.187) and the presence of the IL-8 -251 polymorphism was not associated with AD. However, the OR for AD associated with joint occurrence of the MTHFR 677 T/T and the IL-8 -251 A/A genotypes was 2.512 (95% CI = 1.151-5.483).

CONCLUSION

Our data suggest a critical role for IL-8/MTHFR interactions in the development of AD.

Authors+Show Affiliations

Laboratory of Biochemistry and Molecular Biology, Harbin Engineering University, Harbin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19246914

Citation

Li, Keshen, et al. "Interaction Between Interleukin-8 and Methylenetetrahydrofolate Reductase Genes Modulates Alzheimer's Disease Risk." Dementia and Geriatric Cognitive Disorders, vol. 27, no. 3, 2009, pp. 286-91.
Li K, Liu S, Yao S, et al. Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. Dement Geriatr Cogn Disord. 2009;27(3):286-91.
Li, K., Liu, S., Yao, S., Wang, B., Dai, D., & Yao, L. (2009). Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. Dementia and Geriatric Cognitive Disorders, 27(3), 286-91. https://doi.org/10.1159/000204766
Li K, et al. Interaction Between Interleukin-8 and Methylenetetrahydrofolate Reductase Genes Modulates Alzheimer's Disease Risk. Dement Geriatr Cogn Disord. 2009;27(3):286-91. PubMed PMID: 19246914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulates Alzheimer's disease risk. AU - Li,Keshen, AU - Liu,Shengyuan, AU - Yao,Songpo, AU - Wang,Binyou, AU - Dai,Dawei, AU - Yao,Lifen, Y1 - 2009/02/25/ PY - 2008/12/23/accepted PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2009/5/29/medline SP - 286 EP - 91 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 27 IS - 3 N2 - BACKGROUND/AIM: Interleukin-8 (IL-8), a potent chemoattractant for neutrophils, has been implicated in the pathogenesis of Alzheimer's disease (AD). The ability of individuals to produce high levels of IL-8 is partially determined by the IL-8 -251 T/A polymorphism. Therefore, we investigated the association between this polymorphism and AD in a Chinese population. Additionally, in light of the stimulatory effect of homocysteine on the production of IL-8, we also sought to determine whether the methylenetetrahydrofolate reductase (MTHFR) gene 677 C/T variant, a genetic modifier of the serum homocysteine level, may interact with the IL-8 -251 polymorphism in determining the AD risk. METHODS: Genotyping of 198 AD patients and 240 matched controls was performed by PCR-RFLP. RESULTS: The presence of the MTHFR 677 C/T and 677 T/T genotypes conferred a marginally significant increase in the risk for AD (OR = 1.666, 95% CI = 1.022-2.715, and OR = 1.892, 95% CI = 1.124-3.187) and the presence of the IL-8 -251 polymorphism was not associated with AD. However, the OR for AD associated with joint occurrence of the MTHFR 677 T/T and the IL-8 -251 A/A genotypes was 2.512 (95% CI = 1.151-5.483). CONCLUSION: Our data suggest a critical role for IL-8/MTHFR interactions in the development of AD. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19246914/Interaction_between_interleukin_8_and_methylenetetrahydrofolate_reductase_genes_modulates_Alzheimer's_disease_risk_ L2 - https://www.karger.com?DOI=10.1159/000204766 DB - PRIME DP - Unbound Medicine ER -