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Dietary fiber and stomach cancer risk: a case-control study from Italy.
Cancer Causes Control 2009; 20(6):847-53CC

Abstract

OBJECTIVE

Fiber intake has been inversely related to stomach cancer risk, although this issue is still controversial.

METHODS

A case-control study was conducted in Italy between 1997 and 2007, including 230 cases with incident, histologically confirmed stomach cancer, and 547 controls with acute, non-neoplastic diseases. Dietary habits were investigated through a validated food frequency questionnaire.

RESULTS

Compared with the lowest quintile of intake, the multivariate odds ratios (ORs, including terms for major recognised confounding factors and total energy intake) for the highest quintile were 0.47 (95% confidence interval (CI): 0.28-0.79) for total fiber, 0.50 (95% CI: 0.30-0.85) for soluble non-cellulose polysaccharides (NCP), 0.39 (95% CI: 0.23-0.66) for total insoluble fiber, 0.54 (95% CI: 0.32-0.91) for insoluble NCP, 0.37 (95% CI: 0.22-0.64) for cellulose, and 0.59 (95% CI: 0.36-0.98) for lignin. With reference to the sources of fiber, an inverse association was found for fiber from vegetable (OR = 0.42, 95% CI: 0.24-0.72), and to a lesser extent from fruit (OR = 0.65, 95% CI: 0.38-1.10), but not for fiber from grain (OR = 1.25, 95% CI: 0.77-2.03).

CONCLUSIONS

This study found an inverse relationship between stomach cancer risk and various types of fiber, derived, in particular, from vegetables and fruit.

Authors+Show Affiliations

Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan, MI 20156, Italy. bravi@marionegri.it

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19247788

Citation

Bravi, Francesca, et al. "Dietary Fiber and Stomach Cancer Risk: a Case-control Study From Italy." Cancer Causes & Control : CCC, vol. 20, no. 6, 2009, pp. 847-53.
Bravi F, Scotti L, Bosetti C, et al. Dietary fiber and stomach cancer risk: a case-control study from Italy. Cancer Causes Control. 2009;20(6):847-53.
Bravi, F., Scotti, L., Bosetti, C., Bertuccio, P., Negri, E., & La Vecchia, C. (2009). Dietary fiber and stomach cancer risk: a case-control study from Italy. Cancer Causes & Control : CCC, 20(6), pp. 847-53. doi:10.1007/s10552-009-9309-z.
Bravi F, et al. Dietary Fiber and Stomach Cancer Risk: a Case-control Study From Italy. Cancer Causes Control. 2009;20(6):847-53. PubMed PMID: 19247788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and stomach cancer risk: a case-control study from Italy. AU - Bravi,Francesca, AU - Scotti,Lorenza, AU - Bosetti,Cristina, AU - Bertuccio,Paola, AU - Negri,Eva, AU - La Vecchia,Carlo, Y1 - 2009/02/27/ PY - 2008/05/08/received PY - 2009/01/30/accepted PY - 2009/2/28/entrez PY - 2009/2/28/pubmed PY - 2009/8/20/medline SP - 847 EP - 53 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 6 N2 - OBJECTIVE: Fiber intake has been inversely related to stomach cancer risk, although this issue is still controversial. METHODS: A case-control study was conducted in Italy between 1997 and 2007, including 230 cases with incident, histologically confirmed stomach cancer, and 547 controls with acute, non-neoplastic diseases. Dietary habits were investigated through a validated food frequency questionnaire. RESULTS: Compared with the lowest quintile of intake, the multivariate odds ratios (ORs, including terms for major recognised confounding factors and total energy intake) for the highest quintile were 0.47 (95% confidence interval (CI): 0.28-0.79) for total fiber, 0.50 (95% CI: 0.30-0.85) for soluble non-cellulose polysaccharides (NCP), 0.39 (95% CI: 0.23-0.66) for total insoluble fiber, 0.54 (95% CI: 0.32-0.91) for insoluble NCP, 0.37 (95% CI: 0.22-0.64) for cellulose, and 0.59 (95% CI: 0.36-0.98) for lignin. With reference to the sources of fiber, an inverse association was found for fiber from vegetable (OR = 0.42, 95% CI: 0.24-0.72), and to a lesser extent from fruit (OR = 0.65, 95% CI: 0.38-1.10), but not for fiber from grain (OR = 1.25, 95% CI: 0.77-2.03). CONCLUSIONS: This study found an inverse relationship between stomach cancer risk and various types of fiber, derived, in particular, from vegetables and fruit. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19247788/Dietary_fiber_and_stomach_cancer_risk:_a_case_control_study_from_Italy_ L2 - https://doi.org/10.1007/s10552-009-9309-z DB - PRIME DP - Unbound Medicine ER -