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Placental pathology in egg donor pregnancies.
Fertil Steril. 2010 Feb; 93(2):397-404.FS

Abstract

OBJECTIVE

To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies.

DESIGN

Retrospective case-control study.

SETTING

Academic medical center.

PATIENT(S)

The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry.

RESULT(S)

There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group.

CONCLUSION(S)

There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon.

Authors+Show Affiliations

Department of Pathology, Women and Infants Hospital101 Dudley St. Providence, Rhode Island 02905, USA. fgundogan@wihri.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19249031

Citation

Gundogan, Fusun, et al. "Placental Pathology in Egg Donor Pregnancies." Fertility and Sterility, vol. 93, no. 2, 2010, pp. 397-404.
Gundogan F, Bianchi DW, Scherjon SA, et al. Placental pathology in egg donor pregnancies. Fertil Steril. 2010;93(2):397-404.
Gundogan, F., Bianchi, D. W., Scherjon, S. A., & Roberts, D. J. (2010). Placental pathology in egg donor pregnancies. Fertility and Sterility, 93(2), 397-404. https://doi.org/10.1016/j.fertnstert.2008.12.144
Gundogan F, et al. Placental Pathology in Egg Donor Pregnancies. Fertil Steril. 2010;93(2):397-404. PubMed PMID: 19249031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental pathology in egg donor pregnancies. AU - Gundogan,Fusun, AU - Bianchi,Diana W, AU - Scherjon,Sicco A, AU - Roberts,Drucilla J, Y1 - 2009/02/26/ PY - 2008/09/24/received PY - 2008/12/30/revised PY - 2008/12/31/accepted PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2010/2/25/medline SP - 397 EP - 404 JF - Fertility and sterility JO - Fertil. Steril. VL - 93 IS - 2 N2 - OBJECTIVE: To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies. DESIGN: Retrospective case-control study. SETTING: Academic medical center. PATIENT(S): The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry. RESULT(S): There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group. CONCLUSION(S): There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19249031/Placental_pathology_in_egg_donor_pregnancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)00002-8 DB - PRIME DP - Unbound Medicine ER -