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Aripiprazole in combination with other antipsychotic drugs may worsen psychosis.
J Clin Pharm Ther. 2009 Apr; 34(2):245-6.JC

Abstract

Aripiprazole is a new generation antipsychotic drug with a partial agonist effect on dopamine D2 and D3 receptors. We report the case of a schizophrenic patient whose symptoms worsened after adding aripiprazole to another antipsychotic drug (amisulpiride). The physiopathology of this process seems to be mediated through the dopaminergic effect of aripiprazole in hypodopaminergic environments, caused by the administration of antipsychotic drugs such as amisulpiride. Besides this, the chronic administration of neuroleptic drugs may induce a hypersensitivity to dopamine agonists. In this context, we consider that the dopaminergic effect of aripiprazole may have induced a worsening of psychotic symptoms. We conclude that clinicians should be cautious when adding aripiprazole to patients under treatment with dopamine antagonists with a high affinity for D2 and D3 receptors.

Authors+Show Affiliations

Department of Psychiatry, Hospital Puerta de Hierro, Universidad Autonoma de Madrid, Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19250146

Citation

Adan-Manes, J, and P Garcia-Parajua. "Aripiprazole in Combination With Other Antipsychotic Drugs May Worsen Psychosis." Journal of Clinical Pharmacy and Therapeutics, vol. 34, no. 2, 2009, pp. 245-6.
Adan-Manes J, Garcia-Parajua P. Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. J Clin Pharm Ther. 2009;34(2):245-6.
Adan-Manes, J., & Garcia-Parajua, P. (2009). Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. Journal of Clinical Pharmacy and Therapeutics, 34(2), 245-6. https://doi.org/10.1111/j.1365-2710.2008.00996.x
Adan-Manes J, Garcia-Parajua P. Aripiprazole in Combination With Other Antipsychotic Drugs May Worsen Psychosis. J Clin Pharm Ther. 2009;34(2):245-6. PubMed PMID: 19250146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. AU - Adan-Manes,J, AU - Garcia-Parajua,P, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/6/12/medline SP - 245 EP - 6 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 34 IS - 2 N2 - Aripiprazole is a new generation antipsychotic drug with a partial agonist effect on dopamine D2 and D3 receptors. We report the case of a schizophrenic patient whose symptoms worsened after adding aripiprazole to another antipsychotic drug (amisulpiride). The physiopathology of this process seems to be mediated through the dopaminergic effect of aripiprazole in hypodopaminergic environments, caused by the administration of antipsychotic drugs such as amisulpiride. Besides this, the chronic administration of neuroleptic drugs may induce a hypersensitivity to dopamine agonists. In this context, we consider that the dopaminergic effect of aripiprazole may have induced a worsening of psychotic symptoms. We conclude that clinicians should be cautious when adding aripiprazole to patients under treatment with dopamine antagonists with a high affinity for D2 and D3 receptors. SN - 1365-2710 UR - https://www.unboundmedicine.com/medline/citation/19250146/Aripiprazole_in_combination_with_other_antipsychotic_drugs_may_worsen_psychosis_ L2 - https://doi.org/10.1111/j.1365-2710.2008.00996.x DB - PRIME DP - Unbound Medicine ER -