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The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network.
Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1114-20.IJ

Abstract

PURPOSE

The aim of this study was to assess the outcome of patients with primary spinal myxopapillary ependymoma (MPE).

MATERIALS AND METHODS

Data from a series of 85 (35 females, 50 males) patients with spinal MPE were collected in this retrospective multicenter study. Thirty-eight (45%) underwent surgery only and 47 (55%) received postoperative radiotherapy (RT). Median administered radiation dose was 50.4 Gy (range, 22.2-59.4). Median follow-up of the surviving patients was 60.0 months (range, 0.2-316.6).

RESULTS

The 5-year progression-free survival (PFS) was 50.4% and 74.8% for surgery only and surgery with postoperative low- (<50.4 Gy) or high-dose (>or=50.4 Gy) RT, respectively. Treatment failure was observed in 24 (28%) patients. Fifteen patients presented treatment failure at the primary site only, whereas 2 and 1 patients presented with brain and distant spinal failure only. Three and 2 patients with local failure presented with concomitant spinal distant seeding and brain failure, respectively. One patient failed simultaneously in the brain and spine. Age greater than 36 years (p = 0.01), absence of neurologic symptoms at diagnosis (p = 0.01), tumor size >or=25 mm (p = 0.04), and postoperative high-dose RT (p = 0.05) were variables predictive of improved PFS on univariate analysis. In multivariate analysis, only postoperative high-dose RT was independent predictors of PFS (p = 0.04).

CONCLUSIONS

The observed pattern of failure was mainly local, but one fifth of the patients presented with a concomitant spinal or brain component. Postoperative high-dose RT appears to significantly reduce the rate of tumor progression.

Authors+Show Affiliations

Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

19250760

Citation

Pica, Alessia, et al. "The Results of Surgery, With or Without Radiotherapy, for Primary Spinal Myxopapillary Ependymoma: a Retrospective Study From the Rare Cancer Network." International Journal of Radiation Oncology, Biology, Physics, vol. 74, no. 4, 2009, pp. 1114-20.
Pica A, Miller R, Villà S, et al. The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network. Int J Radiat Oncol Biol Phys. 2009;74(4):1114-20.
Pica, A., Miller, R., Villà, S., Kadish, S. P., Anacak, Y., Abusaris, H., Ozyigit, G., Baumert, B. G., Zaucha, R., Haller, G., & Weber, D. C. (2009). The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network. International Journal of Radiation Oncology, Biology, Physics, 74(4), 1114-20. https://doi.org/10.1016/j.ijrobp.2008.09.034
Pica A, et al. The Results of Surgery, With or Without Radiotherapy, for Primary Spinal Myxopapillary Ependymoma: a Retrospective Study From the Rare Cancer Network. Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1114-20. PubMed PMID: 19250760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network. AU - Pica,Alessia, AU - Miller,Robert, AU - Villà,Salvador, AU - Kadish,Sidney P, AU - Anacak,Yavuz, AU - Abusaris,Huda, AU - Ozyigit,Gokhan, AU - Baumert,Brigitta G, AU - Zaucha,Renata, AU - Haller,Guy, AU - Weber,Damien C, Y1 - 2009/02/26/ PY - 2008/06/13/received PY - 2008/09/04/revised PY - 2008/09/06/accepted PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/7/25/medline SP - 1114 EP - 20 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 74 IS - 4 N2 - PURPOSE: The aim of this study was to assess the outcome of patients with primary spinal myxopapillary ependymoma (MPE). MATERIALS AND METHODS: Data from a series of 85 (35 females, 50 males) patients with spinal MPE were collected in this retrospective multicenter study. Thirty-eight (45%) underwent surgery only and 47 (55%) received postoperative radiotherapy (RT). Median administered radiation dose was 50.4 Gy (range, 22.2-59.4). Median follow-up of the surviving patients was 60.0 months (range, 0.2-316.6). RESULTS: The 5-year progression-free survival (PFS) was 50.4% and 74.8% for surgery only and surgery with postoperative low- (<50.4 Gy) or high-dose (>or=50.4 Gy) RT, respectively. Treatment failure was observed in 24 (28%) patients. Fifteen patients presented treatment failure at the primary site only, whereas 2 and 1 patients presented with brain and distant spinal failure only. Three and 2 patients with local failure presented with concomitant spinal distant seeding and brain failure, respectively. One patient failed simultaneously in the brain and spine. Age greater than 36 years (p = 0.01), absence of neurologic symptoms at diagnosis (p = 0.01), tumor size >or=25 mm (p = 0.04), and postoperative high-dose RT (p = 0.05) were variables predictive of improved PFS on univariate analysis. In multivariate analysis, only postoperative high-dose RT was independent predictors of PFS (p = 0.04). CONCLUSIONS: The observed pattern of failure was mainly local, but one fifth of the patients presented with a concomitant spinal or brain component. Postoperative high-dose RT appears to significantly reduce the rate of tumor progression. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/19250760/The_results_of_surgery_with_or_without_radiotherapy_for_primary_spinal_myxopapillary_ependymoma:_a_retrospective_study_from_the_rare_cancer_network_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(08)03541-4 DB - PRIME DP - Unbound Medicine ER -