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Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women.
Maturitas. 2009 Mar 20; 62(3):301-5.M

Abstract

OBJECTIVES

The aim of this study was to investigate the relationship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in euthyroid postmenopausal women.

METHODS

We conducted a cross-sectional study of 2205 Korean postmenopausal women. Subjects who were not euthyroid were excluded. Fasting TSH, free thyroxine (FT4), insulin, glucose, and the level of insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR) were measured. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.

RESULTS

TSH levels were associated with total cholesterol, LDL-cholesterol, triglycerides and diastolic blood pressure. Using a multiple linear regression analysis, LDL-cholesterol, and triglycerides levels were identified as independently associated with TSH. Multivariate logistic regression analysis determined that TSH levels strongly contributed to MetS. Compared with the lower most quartile (TSH, 0.3-1.44 mIU/L), the adjusted odds ratio for MetS was 1.95 in the upper most quartile (TSH, 2.48-4.00 mIU/L). The prevalence of MetS increased as the TSH quartile showed a gradual increase.

CONCLUSION

We found a close relationship between TSH and MetS in euthyroid postmenopausal women. Therefore, more attention should be focused on postmenopausal women with high normal TSH levels for the management of cardiovascular disease.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19250778

Citation

Park, Hyun Tae, et al. "Thyroid Stimulating Hormone Is Associated With Metabolic Syndrome in Euthyroid Postmenopausal Women." Maturitas, vol. 62, no. 3, 2009, pp. 301-5.
Park HT, Cho GJ, Ahn KH, et al. Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women. Maturitas. 2009;62(3):301-5.
Park, H. T., Cho, G. J., Ahn, K. H., Shin, J. H., Hong, S. C., Kim, T., Hur, J. Y., Kim, Y. T., Lee, K. W., & Kim, S. H. (2009). Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women. Maturitas, 62(3), 301-5. https://doi.org/10.1016/j.maturitas.2009.01.007
Park HT, et al. Thyroid Stimulating Hormone Is Associated With Metabolic Syndrome in Euthyroid Postmenopausal Women. Maturitas. 2009 Mar 20;62(3):301-5. PubMed PMID: 19250778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women. AU - Park,Hyun Tae, AU - Cho,Geum Joon, AU - Ahn,Ki Hoon, AU - Shin,Jung Ho, AU - Hong,Soon Cheol, AU - Kim,Tak, AU - Hur,Jun Young, AU - Kim,Young Tae, AU - Lee,Kyu Wan, AU - Kim,Sun Haeng, Y1 - 2009/02/27/ PY - 2008/07/04/received PY - 2009/01/03/revised PY - 2009/01/06/accepted PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/6/12/medline SP - 301 EP - 5 JF - Maturitas JO - Maturitas VL - 62 IS - 3 N2 - OBJECTIVES: The aim of this study was to investigate the relationship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in euthyroid postmenopausal women. METHODS: We conducted a cross-sectional study of 2205 Korean postmenopausal women. Subjects who were not euthyroid were excluded. Fasting TSH, free thyroxine (FT4), insulin, glucose, and the level of insulin resistance, estimated by the homeostasis model assessment for insulin resistance (HOMA-IR) were measured. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. RESULTS: TSH levels were associated with total cholesterol, LDL-cholesterol, triglycerides and diastolic blood pressure. Using a multiple linear regression analysis, LDL-cholesterol, and triglycerides levels were identified as independently associated with TSH. Multivariate logistic regression analysis determined that TSH levels strongly contributed to MetS. Compared with the lower most quartile (TSH, 0.3-1.44 mIU/L), the adjusted odds ratio for MetS was 1.95 in the upper most quartile (TSH, 2.48-4.00 mIU/L). The prevalence of MetS increased as the TSH quartile showed a gradual increase. CONCLUSION: We found a close relationship between TSH and MetS in euthyroid postmenopausal women. Therefore, more attention should be focused on postmenopausal women with high normal TSH levels for the management of cardiovascular disease. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/19250778/Thyroid_stimulating_hormone_is_associated_with_metabolic_syndrome_in_euthyroid_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(09)00028-0 DB - PRIME DP - Unbound Medicine ER -