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Consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk.
J Formos Med Assoc. 2009 Feb; 108(2):155-63.JF

Abstract

BACKGROUND/PURPOSE

The effect of betel quid chewing on colorectal cancer (CRC) risk has not been reported. In addition, there is no consensus about the causal relationship between smoking or alcohol consumption and CRC risk. This study investigated the impact of betel quid chewing, cigarette smoking or alcohol consumption on CRC risk in Taiwan.

METHODS

Two hundred and fifty-eight patients with pathologically proven CRC (153 men, 105 women; mean age, 63.1 years) were recruited from two hospitals in southern Taiwan. The controls were 533 age- and gender-matched cancer-free subjects from the same hospitals. All subjects were interviewed using a standardized questionnaire to collect demographic and substance use data.

RESULTS

After adjusting for potential confounding factors, smoking (adjusted odds ratio [aOR], 1.65; 95% CI, 1.1-2.3), but not betel quid chewing (aOR, 1.3; 95% CI, 0.7-2.4) or alcohol drinking (aOR, 1.1; 95% CI, 0.7-1.8), was an independent significant risk factor for developing CRC. The significant risk effect of smoking was seen mainly among men, because the frequency of smokers was much higher among Taiwanese men than women.

CONCLUSION

Our results indicated that consumption of cigarettes but not betel quid or alcohol was a risk factor for male CRC. A large study is necessary to investigate the risk factors for female CRC in Taiwan, and to understand the effect of betel quid exposure on male CRC.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Graduate Institutes of Medicine, College of Medicine, Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19251551

Citation

Wu, I-Chen, et al. "Consumption of Cigarettes but Not Betel Quid or Alcohol Increases Colorectal Cancer Risk." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 108, no. 2, 2009, pp. 155-63.
Wu IC, Lee CH, Kuo CH, et al. Consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk. J Formos Med Assoc. 2009;108(2):155-63.
Wu, I. C., Lee, C. H., Kuo, C. H., Kuo, F. C., Wu, D. C., Ko, Y. C., & Yu, F. J. (2009). Consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 108(2), 155-63. https://doi.org/10.1016/S0929-6646(09)60046-2
Wu IC, et al. Consumption of Cigarettes but Not Betel Quid or Alcohol Increases Colorectal Cancer Risk. J Formos Med Assoc. 2009;108(2):155-63. PubMed PMID: 19251551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk. AU - Wu,I-Chen, AU - Lee,Chien-Hung, AU - Kuo,Chao-Hung, AU - Kuo,Fu-Chen, AU - Wu,Deng-Chyang, AU - Ko,Ying-Chin, AU - Yu,Fang-Jung, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/5/14/medline SP - 155 EP - 63 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 108 IS - 2 N2 - BACKGROUND/PURPOSE: The effect of betel quid chewing on colorectal cancer (CRC) risk has not been reported. In addition, there is no consensus about the causal relationship between smoking or alcohol consumption and CRC risk. This study investigated the impact of betel quid chewing, cigarette smoking or alcohol consumption on CRC risk in Taiwan. METHODS: Two hundred and fifty-eight patients with pathologically proven CRC (153 men, 105 women; mean age, 63.1 years) were recruited from two hospitals in southern Taiwan. The controls were 533 age- and gender-matched cancer-free subjects from the same hospitals. All subjects were interviewed using a standardized questionnaire to collect demographic and substance use data. RESULTS: After adjusting for potential confounding factors, smoking (adjusted odds ratio [aOR], 1.65; 95% CI, 1.1-2.3), but not betel quid chewing (aOR, 1.3; 95% CI, 0.7-2.4) or alcohol drinking (aOR, 1.1; 95% CI, 0.7-1.8), was an independent significant risk factor for developing CRC. The significant risk effect of smoking was seen mainly among men, because the frequency of smokers was much higher among Taiwanese men than women. CONCLUSION: Our results indicated that consumption of cigarettes but not betel quid or alcohol was a risk factor for male CRC. A large study is necessary to investigate the risk factors for female CRC in Taiwan, and to understand the effect of betel quid exposure on male CRC. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/19251551/Consumption_of_cigarettes_but_not_betel_quid_or_alcohol_increases_colorectal_cancer_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(09)60046-2 DB - PRIME DP - Unbound Medicine ER -