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Laboratory data in children with Lyme neuroborreliosis, relation to clinical presentation and duration of symptoms.
Scand J Infect Dis. 2009; 41(5):355-62.SJ

Abstract

The occurrence of IgM and IgG antibodies against Borrelia burgdoferi in serum and cerebrospinal fluid (CSF) and intrathecal synthesis of antibodies (antibody index) were studied in relation to clinical presentation and the duration of symptoms before diagnosis in 146 children diagnosed with neuroborreliosis. Lymphocytic meningitis was demonstrated in 141 of these children. Levels of white blood cells (WBC) and protein in CSF correlated significantly to numbers of d with symptoms. Children were divided into 3 clinical groups: A (n = 37): only cranial neuropathy; B (n = 68): both cranial neuropathy and other neurological symptoms; C (n = 41): neurological symptoms without cranial neuropathy. Levels of WBC and protein in CSF as well as the proportion of children with antibodies in serum and CSF were generally lowest in group A, intermediate in group B and highest in group C. The proportion of children with antibodies in serum and CSF and a positive antibody index was also related to duration of symptoms; the antibody index was present in 51% of children with symptoms < or = 7 d, and in 80% of children with symptoms > 7 d (p<0.01). The clinical presentation and duration of symptoms must be considered when interpreting laboratory data in children with suspected neuroborreliosis.

Authors+Show Affiliations

Departments of Paediatrics, University of Bergen, Norway.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19253089

Citation

Tveitnes, Dag, et al. "Laboratory Data in Children With Lyme Neuroborreliosis, Relation to Clinical Presentation and Duration of Symptoms." Scandinavian Journal of Infectious Diseases, vol. 41, no. 5, 2009, pp. 355-62.
Tveitnes D, Øymar K, Natås O. Laboratory data in children with Lyme neuroborreliosis, relation to clinical presentation and duration of symptoms. Scand J Infect Dis. 2009;41(5):355-62.
Tveitnes, D., Øymar, K., & Natås, O. (2009). Laboratory data in children with Lyme neuroborreliosis, relation to clinical presentation and duration of symptoms. Scandinavian Journal of Infectious Diseases, 41(5), 355-62. https://doi.org/10.1080/00365540902787666
Tveitnes D, Øymar K, Natås O. Laboratory Data in Children With Lyme Neuroborreliosis, Relation to Clinical Presentation and Duration of Symptoms. Scand J Infect Dis. 2009;41(5):355-62. PubMed PMID: 19253089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laboratory data in children with Lyme neuroborreliosis, relation to clinical presentation and duration of symptoms. AU - Tveitnes,Dag, AU - Øymar,Knut, AU - Natås,Olav, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/7/3/medline SP - 355 EP - 62 JF - Scandinavian journal of infectious diseases JO - Scand J Infect Dis VL - 41 IS - 5 N2 - The occurrence of IgM and IgG antibodies against Borrelia burgdoferi in serum and cerebrospinal fluid (CSF) and intrathecal synthesis of antibodies (antibody index) were studied in relation to clinical presentation and the duration of symptoms before diagnosis in 146 children diagnosed with neuroborreliosis. Lymphocytic meningitis was demonstrated in 141 of these children. Levels of white blood cells (WBC) and protein in CSF correlated significantly to numbers of d with symptoms. Children were divided into 3 clinical groups: A (n = 37): only cranial neuropathy; B (n = 68): both cranial neuropathy and other neurological symptoms; C (n = 41): neurological symptoms without cranial neuropathy. Levels of WBC and protein in CSF as well as the proportion of children with antibodies in serum and CSF were generally lowest in group A, intermediate in group B and highest in group C. The proportion of children with antibodies in serum and CSF and a positive antibody index was also related to duration of symptoms; the antibody index was present in 51% of children with symptoms < or = 7 d, and in 80% of children with symptoms > 7 d (p<0.01). The clinical presentation and duration of symptoms must be considered when interpreting laboratory data in children with suspected neuroborreliosis. SN - 0036-5548 UR - https://www.unboundmedicine.com/medline/citation/19253089/Laboratory_data_in_children_with_Lyme_neuroborreliosis_relation_to_clinical_presentation_and_duration_of_symptoms_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365540902787666 DB - PRIME DP - Unbound Medicine ER -