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The role of the oxidative-stress in the endometriosis-related infertility.

Abstract

Endometriosis is a common gynecological disorder of the reproductive age characterised by pelvic pain, dysmenorrhea and infertility. Classic theories have failed to propose a precise pathogenetic mechanism. Recent studies have investigated the role of the immune system and oxidative stress in the development of endometriosis as well as the identification of biomarkers for a non-invasive diagnosis of the disease. At endometriotic sites, inflammatory cells including eosinophils, neutrophils and macrophages generate reactive oxygen species that contribute to the development of oxidative stress in the peritoneal cavity. Oxidative stress further augments immune response in affected sites. The oxidants exacerbate the development of endometriosis by inducing chemoattractants and endometrial cell growth-promoting activity. The oxidative proinflammatory state of the peritoneal fluid is an important mediator of endometriosis. Many studies investigate the correlation of endometriosis and oxidative stress but the results are discrepant. Furthermore, oxidative stress has been implicated in unexplained infertility and has been associated with some of its causative factors. Oxidative stress influences women's reproductive capacity. The association between endometriosis and infertility is described in several studies and still remains debated.

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  • Authors+Show Affiliations

    ,

    2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University Medical School, Athens, Greece. aretiaugoulea@yahoo.gr

    , , ,

    Source

    MeSH

    Endometriosis
    Female
    Humans
    Infertility, Female
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19253102

    Citation

    Augoulea, Areti, et al. "The Role of the Oxidative-stress in the Endometriosis-related Infertility." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 2, 2009, pp. 75-81.
    Augoulea A, Mastorakos G, Lambrinoudaki I, et al. The role of the oxidative-stress in the endometriosis-related infertility. Gynecol Endocrinol. 2009;25(2):75-81.
    Augoulea, A., Mastorakos, G., Lambrinoudaki, I., Christodoulakos, G., & Creatsas, G. (2009). The role of the oxidative-stress in the endometriosis-related infertility. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(2), pp. 75-81. doi:10.1080/09513590802485012.
    Augoulea A, et al. The Role of the Oxidative-stress in the Endometriosis-related Infertility. Gynecol Endocrinol. 2009;25(2):75-81. PubMed PMID: 19253102.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of the oxidative-stress in the endometriosis-related infertility. AU - Augoulea,Areti, AU - Mastorakos,George, AU - Lambrinoudaki,Irene, AU - Christodoulakos,George, AU - Creatsas,George, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/6/20/medline SP - 75 EP - 81 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 25 IS - 2 N2 - Endometriosis is a common gynecological disorder of the reproductive age characterised by pelvic pain, dysmenorrhea and infertility. Classic theories have failed to propose a precise pathogenetic mechanism. Recent studies have investigated the role of the immune system and oxidative stress in the development of endometriosis as well as the identification of biomarkers for a non-invasive diagnosis of the disease. At endometriotic sites, inflammatory cells including eosinophils, neutrophils and macrophages generate reactive oxygen species that contribute to the development of oxidative stress in the peritoneal cavity. Oxidative stress further augments immune response in affected sites. The oxidants exacerbate the development of endometriosis by inducing chemoattractants and endometrial cell growth-promoting activity. The oxidative proinflammatory state of the peritoneal fluid is an important mediator of endometriosis. Many studies investigate the correlation of endometriosis and oxidative stress but the results are discrepant. Furthermore, oxidative stress has been implicated in unexplained infertility and has been associated with some of its causative factors. Oxidative stress influences women's reproductive capacity. The association between endometriosis and infertility is described in several studies and still remains debated. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19253102/The_role_of_the_oxidative_stress_in_the_endometriosis_related_infertility_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802485012 DB - PRIME DP - Unbound Medicine ER -