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Maternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia.
J Matern Fetal Neonatal Med. 2009 Feb; 22(2):175-7.JM

Abstract

Thrombocytopenia-absent radius (TAR) syndrome affects 0.5-1/100,000 live births. We describe, to the best of our knowledge, the sixth patient with TAR to experience a successful pregnancy and the first such case complicated by severe pre-eclampsia. The diagnosis of pre-eclampsia was made at 33 weeks by blood pressure and proteinuria. A further decline in platelets suggested, but could not reliably confirm, severe pre-eclampsia until she experienced persistently elevated aspartate aminotransferase levels. Repeat cesarean delivery was performed at 33 4/7 weeks' gestation. Obstetrical conditions characterised by thrombocytopenia may present diagnostic challenges and should be considered in the differential diagnosis of thrombocytopenic exacerbations in TAR syndrome.

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Publisher Full Text

Authors+Show Affiliations

Wax JR
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA. waxj@mmc.org
Crabtree C
No affiliation info available
Blackstone J
No affiliation info available
Pinette MG
No affiliation info available
Cartin A
No affiliation info available

MeSH

AdultAspartate AminotransferasesCesarean SectionFemaleHumansInfant, NewbornMalePlatelet TransfusionPre-EclampsiaPregnancyPregnancy Complications, HematologicRadiusSeverity of Illness IndexThrombocytopenia

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19253167

Citation

Wax, Joseph R., et al. "Maternal Thrombocytopenia-absent Radius Syndrome Complicated By Severe Pre-eclampsia." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 22, no. 2, 2009, pp. 175-7.
Wax JR, Crabtree C, Blackstone J, et al. Maternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia. J Matern Fetal Neonatal Med. 2009;22(2):175-7.
Wax, J. R., Crabtree, C., Blackstone, J., Pinette, M. G., & Cartin, A. (2009). Maternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 22(2), 175-7. https://doi.org/10.1080/14767050802524578
Wax JR, et al. Maternal Thrombocytopenia-absent Radius Syndrome Complicated By Severe Pre-eclampsia. J Matern Fetal Neonatal Med. 2009;22(2):175-7. PubMed PMID: 19253167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia. AU - Wax,Joseph R, AU - Crabtree,Chelsea, AU - Blackstone,Jacquelyn, AU - Pinette,Michael G, AU - Cartin,Angelina, PY - 2009/3/3/entrez PY - 2009/3/3/pubmed PY - 2009/6/19/medline SP - 175 EP - 7 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 22 IS - 2 N2 - Thrombocytopenia-absent radius (TAR) syndrome affects 0.5-1/100,000 live births. We describe, to the best of our knowledge, the sixth patient with TAR to experience a successful pregnancy and the first such case complicated by severe pre-eclampsia. The diagnosis of pre-eclampsia was made at 33 weeks by blood pressure and proteinuria. A further decline in platelets suggested, but could not reliably confirm, severe pre-eclampsia until she experienced persistently elevated aspartate aminotransferase levels. Repeat cesarean delivery was performed at 33 4/7 weeks' gestation. Obstetrical conditions characterised by thrombocytopenia may present diagnostic challenges and should be considered in the differential diagnosis of thrombocytopenic exacerbations in TAR syndrome. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/19253167/Maternal_thrombocytopenia_absent_radius_syndrome_complicated_by_severe_pre_eclampsia_ L2 - https://www.tandfonline.com/doi/full/10.1080/14767050802524578 DB - PRIME DP - Unbound Medicine ER -